Evidence map›Paper›PMID 38928167›Full record

ArticleInternational journal of molecular sciences2024

Maternal Hypermethylated Genes Contribute to Intrauterine Growth Retardation of Piglets in Rongchang Pigs.

Pingxian Wu, Junge Wang, Xiang Ji, Jie Chai, Li Chen, Tinghuan Zhang, Xi Long, Zhi Tu, Siqing Chen, Lijuan Zhang and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pingxian WuChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Junge WangFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0009-0001-3653-5424
Xiang JiFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
Jie ChaiChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Li ChenChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Tinghuan ZhangChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Xi LongChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Zhi TuChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Siqing ChenChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Lijuan ZhangChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Ketian WangChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Liang ZhangChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Zongyi GuoChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.
Jinyong WangChongqing Academy of Animal Sciences, Rongchang, Chongqing 402460, China.

Funding

National Center of Technology Innovation for Pigs NCTIP-XD/B01
6 · The paper itself

Abstract

The placenta is a crucial determinant of fetal survival, growth, and development. Deficiency in placental development directly causes intrauterine growth retardation (IUGR). IUGR can lead to fetal growth restriction and an increase in the mortality rate. The genetic mechanisms underlying IUGR development, however, remain unclear. In the present study, we integrated whole-genome DNA methylation and transcriptomic analyses to determine distinct gene expression patterns in various placental tissues to identify pivotal genes that are implicated with IUGR development. By performing RNA-sequencing analysis, 1487 differentially expressed genes (DEGs), with 737 upregulated and 750 downregulated genes, were identified in IUGR pigs (H_IUGR) compared with that in normal birth weight pigs (N_IUGR) (

Indexed as

DNA MethylationFetal Growth RetardationPlacentaAnimalsEpigenesis, GeneticFemaleGene Expression ProfilingGene Regulatory NetworksMicroRNAsPregnancyProtein Interaction MapsSwineTranscriptomeMicroRNAsDNA methylationintrauterine growth retardationplacentaRongchang pigstranscriptome

Identifiers

PMID38928167
PMCPMC11203632

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.