Evidence map›Paper›PMID 38928145›Full record

ArticleInternational journal of molecular sciences2024

The Uniform Distribution of Hydroxyapatite in a Polyurethane Foam-Based Scaffold (PU/HAp) to Enhance Bone Repair in a Calvarial Defect Model.

Chiu-Fang Chen, Ya-Shuan Chou, Tzer-Min Lee, Yin-Chih Fu, Shih-Fu Ou, Szu-Hsien Chen, Tien-Ching Lee, Yan-Hsiung Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chiu-Fang ChenSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.ORCID 0000-0003-4412-0795
Ya-Shuan ChouOrthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0002-0462-895X
Tzer-Min LeeInstitute of Oral Medicine, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan.ORCID 0000-0002-1873-9685
Yin-Chih FuOrthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0001-9600-7140
Shih-Fu OuDepartment of Mold and Die Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 807, Taiwan.ORCID 0000-0001-5294-3113
Szu-Hsien ChenInstitute of Polymer Science and Engineering, College of Engineering, National Taiwan University, Taipei 106216, Taiwan.
Tien-Ching LeeOrthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0002-1510-8079
Yan-Hsiung WangSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.ORCID 0000-0001-8161-7472

Funding

National Science and Technology of Taiwan MOST111-2314-B-037-045, NSTC112-2314-B-037-114-MY3 and NSTC 112-2622-B-037-003-Orthopedic Research Center and the Regenerative Medicine and Cell Therapy Research Center KMU-TC108A02
6 · The paper itself

Abstract

Polyurethane (PU) is a promising material for addressing challenges in bone grafting. This study was designed to enhance the bone grafting capabilities of PU by integrating hydroxyapatite (HAp), which is known for its osteoconductive and osteoinductive potential. Moreover, a uniform distribution of HAp in the porous structure of PU increased the effectiveness of bone grafts. PEG/APTES-modified scaffolds were prepared through self-foaming reactions. A uniform pore structure was generated during the spontaneous foaming reaction, and HAp was uniformly distributed in the PU structure (PU15HAp and PU30HAp) during foaming. Compared with the PU scaffolds, the HAp-modified PU scaffolds exhibited significantly greater protein absorption. Importantly, the effect of the HAp-modified PU scaffold on bone repair was tested in a rat calvarial defect model. The microstructure of the newly formed bone was analyzed with microcomputed tomography (μ-CT). Bone regeneration at the defect site was significantly greater in the HAp-modified PU scaffold group than in the PU group. This innovative HAp-modified PU scaffold improves current bone graft materials, providing a promising avenue for improved bone regeneration.

Indexed as

Bone RegenerationDurapatitePolyurethanesSkullTissue ScaffoldsAnimalsBone TransplantationMalePorosityRatsRats, Sprague-DawleyX-Ray MicrotomographyDurapatitepolyurethane foamPolyurethanesbone graftingbone regenerationhydroxyapatitepolyurethane

Identifiers

PMID38928145
PMCPMC11203484

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.