Evidence map›Paper›PMID 38928144›Full record

ArticleInternational journal of molecular sciences2024

Integrated miRNA-mRNA Analysis Reveals Critical miRNAs and Targets in Diet-Induced Obesity-Related Glomerulopathy.

Marina López-Martínez, Maria Pilar Armengol, Irina Pey, Xavier Farré, Paula Rodríguez-Martínez, Mireia Ferrer, Esteban Porrini, Sergio Luis-Lima, Laura Díaz-Martín, Ana Elena Rodríguez-Rodríguez and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Obesity-Related Kidney Disease: A Growing Threat to Renal Health.International journal of molecular sciences · 2025
    Review
  4. Obesity-related glomerulopathy: How it happens and future perspectives.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marina López-MartínezCSUR National Unit of Expertise for Complex Glomerular Diseases of Spain, Nephrology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Research, 08035 Barcelona, Spain.
Maria Pilar ArmengolGenomic Platform, Germans Trias i Pujol's Research Institute, Badalona, 08916 Barcelona, Spain.ORCID 0000-0002-9423-2966
Irina PeyGenomic Platform, Germans Trias i Pujol's Research Institute, Badalona, 08916 Barcelona, Spain.
Xavier FarréGenomic Platform, Germans Trias i Pujol's Research Institute, Badalona, 08916 Barcelona, Spain.
Paula Rodríguez-MartínezPathology Department, Germans Trias i Pujol Hospital, Badalona, 08916 Barcelona, Spain.
Mireia FerrerStatistics and Bioinformatics Unit, Vall d'Hebron Research Institute, 08035 Barcelona, Spain.
Esteban PorriniLaboratory of Renal Function (LFR), Faculty of Medicine, University of La Laguna, Complejo Hospitalario Universitario de Canarias, 38320 La Laguna, Spain.
Sergio Luis-LimaLaboratory of Renal Function (LFR), Faculty of Medicine, University of La Laguna, Complejo Hospitalario Universitario de Canarias, 38320 La Laguna, Spain.
Laura Díaz-MartínLaboratory of Renal Function (LFR), Faculty of Medicine, University of La Laguna, Complejo Hospitalario Universitario de Canarias, 38320 La Laguna, Spain.
Ana Elena Rodríguez-RodríguezResearch Unit, Hospital Universitario de Canarias, La Laguna, 38320 Tenerife, Spain.ORCID 0000-0002-0803-864X
Coriolano Cruz-PereraLaboratory of Renal Function (LFR), Faculty of Medicine, University of La Laguna, Complejo Hospitalario Universitario de Canarias, 38320 La Laguna, Spain.
Marta AlcaldeComparative Medicine and Bioimage Centre of Catalonia (CMCiB), Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain.
Maruja Navarro-DíazGenomic Platform, Germans Trias i Pujol's Research Institute, Badalona, 08916 Barcelona, Spain.

Funding

Instituto de Salud Carlos III PI18/01951
6 · The paper itself

Abstract

This study aimed to investigate obesity-related glomerulopathy (ORG) at cellular, structural, and transcriptomic levels. Thirty Wistar rats were randomized into two groups: 15 rats were fed with a standard diet (SD-rats), and 15 rats were fed with a high-fat diet (HFD-rats). After 10 weeks, the weight, kidney function, histological features, and transcriptomic changes were assessed. HFD-rats gained significantly more weight (55.8% vs. 29.2%;

Indexed as

Diet, High-FatMicroRNAsObesityPodocytesRats, WistarRNA, MessengerAnimalsGene Expression ProfilingGene Expression RegulationKidney DiseasesMalePTEN PhosphohydrolaseRatsTranscriptomeMicroRNAsPTEN PhosphohydrolaseRNA, Messengerbiomarkermesangial matrix increasemicroRNAobesity-related glomerulopathypodocyte hypertrophytargetomeWistar rats

Identifiers

PMID38928144
PMCPMC11204096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.