Genetic Profiling of Sebaceous Carcinoma Arising from an Ovarian Mature Teratoma: A Case Report.

Sumika Zaitsu, Yoko Aoyagi, Haruto Nishida, Kohei Nakamura, Mitsutake Yano, Eiji Kobayashi

Abstract readCase Reports

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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5 · Who and what money

Authors and funding

6 authors.

Sumika ZaitsuDepartment of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.

Yoko AoyagiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.

Haruto NishidaDepartment of Diagnostic Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.ORCID 0000-0003-2959-8002

Kohei NakamuraGenomics Unit, Keio Cancer Center, School of Medicine, Keio University, Tokyo 160-8582, Japan.ORCID 0000-0002-5162-7132

Mitsutake YanoDepartment of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.ORCID 0000-0002-4436-838X

Eiji KobayashiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.

Funding

Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology 22K15409

6 · The paper itself

Abstract

Ovarian mature teratomas (OMTs) originate from post-meiotic germ cells. Malignant transformation occurs in approximately 1-2% of OMTs; however, sebaceous carcinoma arising from OMTs is rare. This is the first report of a detailed genomic analysis of sebaceous carcinoma arising from an OMT. A 36-year-old woman underwent evaluation for abdominal tumors and subsequent hysterectomy and salpingo-oophorectomy. Pathologically, a diagnosis of stage IA sebaceous carcinoma arising from an OMT was established. Eight months post-surgery, the patient was alive without recurrence. Immunohistochemically, the tumor was negative for mismatch repair proteins. A nonsense mutation in

Indexed as

Ovarian NeoplasmsTeratomaTumor Suppressor Protein p53Adenocarcinoma, SebaceousAdultCell Transformation, NeoplasticClass Ia Phosphatidylinositol 3-KinaseFemaleHumansPolymorphism, Single NucleotideClass Ia Phosphatidylinositol 3-KinasePIK3R1 protein, humanTP53 protein, humanTumor Suppressor Protein p53malignant transformation: endoreduplicationovarian teratomaPIK3R1sebaceous carcinomaTP53uniparental disomy

Identifiers

PMID38928057

DOI10.3390/ijms25126351

PMCPMC11203495

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