Evidence map›Paper›PMID 38927989›Full record

ArticleCancers2024

Exploring miRNA Profiles in Colon Cancer: A Focus on miR101-3p, miR106a-5p, and miR326.

Constantin-Dan Tâlvan, Elena-Teodora Tâlvan, Călin Ilie Mohor, Liviuța Budișan, Valentin Grecu, Manuela Mihalache, Oana Zănoagă, Sergiu Chira, Ioana Berindan-Neagoe, Victor Cristea and 1 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Constantin-Dan TâlvanFaculty of Medicine, "Lucian Blaga" University of Sibiu, 550169 Sibiu, Romania.
Elena-Teodora TâlvanFaculty of Medicine, "Lucian Blaga" University of Sibiu, 550169 Sibiu, Romania.
Călin Ilie MohorFaculty of Medicine, "Lucian Blaga" University of Sibiu, 550169 Sibiu, Romania.
Liviuța BudișanResearch Center for Functional Genomic, Biomedicine and Translational Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-5725-662X
Valentin GrecuFaculty of Engineering, "Lucian Blaga" University of Sibiu, 550025 Sibiu, Romania.ORCID 0000-0003-3997-1691
Manuela MihalacheFaculty of Medicine, "Lucian Blaga" University of Sibiu, 550169 Sibiu, Romania.
Oana ZănoagăResearch Center for Functional Genomic, Biomedicine and Translational Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania.
Sergiu ChiraResearch Center for Functional Genomic, Biomedicine and Translational Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania.
Ioana Berindan-NeagoeResearch Center for Functional Genomic, Biomedicine and Translational Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-5828-1325
Victor CristeaResearch Center for Functional Genomic, Biomedicine and Translational Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania.
Cosmin Ioan MohorFaculty of Medicine, "Lucian Blaga" University of Sibiu, 550169 Sibiu, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early diagnosis and prognosis of cancer progression through biomarker profiling are crucial in managing colon cancer patients. Our research aimed to investigate the expression of miR-101-3p, miR-106a-5p, and miR-326 in tumor and adjacent healthy tissues of colon cancer patients and determine their potential diagnostic utility. This study included 40 patients divided into four groups according to the TNM staging classification. MiRNA expression was analyzed using qRT-PCR. The results showed that miR-101-3p, miR-106a-5p, and miR-326 are overexpressed in adjacent healthy tissues but decrease in advanced cancer stages. MiR-106a-5p and miR-326 are strongly correlated with colon cancer severity. These findings suggest that miRNA profiling could be useful for early diagnosis and prognosis in colon cancer management.

Indexed as

biomarkerscolon cancermiRNAsstagingtissue

Identifiers

PMID38927989
PMCPMC11201595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.