Evidence map›Paper›PMID 38927962›Full record

ArticleCancers2024

Complex Karyotype Detection in Chronic Lymphocytic Leukemia: A Comparison of Parallel Cytogenetic Cultures Using TPA and IL2+DSP30 from a Single Center.

Joanna Kamaso, Anna Puiggros, Marta Salido, Carme Melero, María Rodríguez-Rivera, Eva Gimeno, Laia Martínez, Leonor Arenillas, Xavier Calvo, David Román and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Joanna KamasoMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.
Anna PuiggrosMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0001-9627-4978
Marta SalidoMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.
Carme MeleroMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.
María Rodríguez-RiveraMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.
Eva GimenoDepartment of Hematology, Hospital del Mar, 08003 Barcelona, Spain.
Laia MartínezHematology Service, Hospital Universitari Sant Joan de Reus, 43204 Reus, Spain.
Leonor ArenillasMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0002-8176-7179
Xavier CalvoMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0001-7934-9130
David RománMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.
Eugènia AbellaDepartment of Hematology, Hospital del Mar, 08003 Barcelona, Spain.
Silvia Ramos-CampoyMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.
Marta LorenzoMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.
Ana FerrerMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.
Rosa ColladoDepartment of Hematology, Consorcio Hospital General Universitario Valencia, 46014 Valencia, Spain.ORCID 0000-0002-8205-6192
Marco Antonio Moro-GarcíaLaboratory Medicine Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.ORCID 0000-0001-9601-5757
Blanca EspinetMolecular Cytogenetics and Hematological Cytology Laboratories, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0002-4294-8145

Funding

Generalitat de Catalunya 21SGR25Gilead Sciences Fellowship GLD17/00282
6 · The paper itself

Abstract

Current CLL guidelines recommend a two parallel cultures assessment using TPA and IL2+DSP30 mitogens for complex karyotype (CK) detection. Studies comparing both mitogens for CK identification in the same cohort are lacking. We analyzed the global performance, CK detection, and concordance in the complexity assessment of two cytogenetic cultures from 255 CLL patients. IL2+DSP30 identified more altered karyotypes than TPA (50 vs. 39%,

Indexed as

(3–10): mitogenchromosome banding analysischronic lymphocytic leukemiacomplex karyotypeDSP30IL2TPA

Identifiers

PMID38927962
PMCPMC11202013

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.