Evidence map›Paper›PMID 38927927›Full record

ArticleCancers2024

Ensemble Deep Learning-Based Image Classification for Breast Cancer Subtype and Invasiveness Diagnosis from Whole Slide Image Histopathology.

Aadhi Aadhavan Balasubramanian, Salah Mohammed Awad Al-Heejawi, Akarsh Singh, Anne Breggia, Bilal Ahmad, Robert Christman, Stephen T Ryan, Saeed Amal

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aadhi Aadhavan BalasubramanianKhoury College of Computer Sciences, Northeastern University, Boston, MA 02115, USA.
Salah Mohammed Awad Al-HeejawiCollege of Engineering, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0003-1949-6715
Akarsh SinghCollege of Engineering, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0002-4735-3343
Anne BreggiaMaineHealth Institute for Research, Scarborough, ME 04074, USA.
Bilal AhmadMaine Medical Center, Portland, ME 04102, USA.
Robert ChristmanMaine Medical Center, Portland, ME 04102, USA.
Stephen T RyanMaine Medical Center, Portland, ME 04102, USA.
Saeed AmalThe Roux Institute, Department of Bioengineering, College of Engineering, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0001-8703-6986

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer diagnosis and classification are pivotal for effective patient management and treatment planning. In this study, a comprehensive approach is presented utilizing ensemble deep learning techniques to analyze breast cancer histopathology images. Our datasets were based on two widely employed datasets from different centers for two different tasks: BACH and BreakHis. Within the BACH dataset, a proposed ensemble strategy was employed, incorporating VGG16 and ResNet50 architectures to achieve precise classification of breast cancer histopathology images. Introducing a novel image patching technique to preprocess a high-resolution image facilitated a focused analysis of localized regions of interest. The annotated BACH dataset encompassed 400 WSIs across four distinct classes: Normal, Benign, In Situ Carcinoma, and Invasive Carcinoma. In addition, the proposed ensemble was used on the BreakHis dataset, utilizing VGG16, ResNet34, and ResNet50 models to classify microscopic images into eight distinct categories (four benign and four malignant). For both datasets, a five-fold cross-validation approach was employed for rigorous training and testing. Preliminary experimental results indicated a patch classification accuracy of 95.31% (for the BACH dataset) and WSI image classification accuracy of 98.43% (BreakHis). This research significantly contributes to ongoing endeavors in harnessing artificial intelligence to advance breast cancer diagnosis, potentially fostering improved patient outcomes and alleviating healthcare burdens.

Indexed as

artificial intelligencebreast cancer diagnosiscomputer visiondigital pathologyensemble deep learningfoundation modelshistopathology imagesimage processing

Identifiers

PMID38927927
PMCPMC11201924

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.