Evidence map›Paper›PMID 38927911›Full record

ReviewCancers2024

Promising Combinatorial Therapeutic Strategies against Non-Small Cell Lung Cancer.

Prabhjot Kaur, Santosh Kumar Singh, Manoj K Mishra, Shailesh Singh, Rajesh Singh

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Prabhjot KaurDepartment of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Santosh Kumar SinghDepartment of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA.ORCID 0000-0003-0358-0138
Manoj K MishraCancer Biology Research and Training, Department of Biological Sciences, Alabama State University, Montgomery, AL 36014, USA.ORCID 0000-0001-7563-6474
Shailesh SinghDepartment of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Rajesh SinghDepartment of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA.ORCID 0000-0002-0397-3794

Funding

Research Training & Career Development ProgramU54CA118638 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI Brian M. Rivers · 2005 to 2026
$22.7M
The interplay of social and molecular determinants in lung cancer disparityR01CA256724 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI Brian M. Rivers, Rajesh Singh · 2022 to 2026
$2.3M
Targeted Nanotherapy for prostate cancerSC1CA193758 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI SINGH, RAJESH · 2014 to 2017
$1.4M
NCI NIH HHS R01 CA256724NCI NIH HHS SC1 CA193758NCI NIH HHS U54 CA118638the American Cancer Society CHERC-MSI-21-166-01-CHERC-MSIthe Department of Defense W81XWH1810429the National Cancer Institute R01CA256724the National Institutes of Health SC1CA193758 and U54CA118638
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) presents a complex and diverse disease, exhibiting variations at individuals' cellular and histological levels. This complexity gives rise to different subtypes and genetic mutations, posing challenges for accurate diagnosis and effective treatment. Nevertheless, continuous progress in medical research and therapies is continually shaping the landscape of NSCLC diagnosis and management. The treatment of NSCLC has undergone significant advancements in recent years, especially with the emergence of targeted therapies that have shown remarkable efficacy in patients with actionable mutations. This has ushered in the era of personalized medicine in NSCLC treatment, with improvements in molecular and immunohistochemical techniques contributing to enhanced progression-free survival. This review focuses on the latest progress, challenges, and future directions in developing targeted therapies for NSCLC, including tyrosine kinase inhibitors (TKIs), DNA-damaging agents, immunotherapy regimens, natural drug therapy, and nanobodies. Furthermore, recent randomized studies have demonstrated enhanced overall survival in patients receiving different targeted and natural drug therapies.

Indexed as

clinical trialsimmune checkpoint inhibitorsnanobodiesnatural drug therapyPARP inhibitorsPDL-1tyrosine kinase inhibitors

Identifiers

PMID38927911
PMCPMC11201636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.