Evidence map›Paper›PMID 38927878›Full record

ReviewCancers2024

Wire-Free Targeted Axillary Dissection: A Pooled Analysis of 1300+ Cases Post-Neoadjuvant Systemic Therapy in Node-Positive Early Breast Cancer.

Jajini Varghese, Neill Patani, Umar Wazir, Shonnelly Novintan, Michael J Michell, Anmol Malhotra, Kinan Mokbel, Kefah Mokbel

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Axillary management in patients with sentinel lymph node micrometastases following neoadjuvant systemic therapy: a call for de-escalation.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jajini VargheseThe London Breast Institute, The Women's Health Centre, HCA Healthcare UK, London W1U 9QP, UK.
Neill PataniThe London Breast Institute, The Women's Health Centre, HCA Healthcare UK, London W1U 9QP, UK.
Umar WazirThe London Breast Institute, The Women's Health Centre, HCA Healthcare UK, London W1U 9QP, UK.ORCID 0000-0001-8979-692X
Shonnelly NovintanThe London Breast Institute, The Women's Health Centre, HCA Healthcare UK, London W1U 9QP, UK.
Michael J MichellThe London Breast Institute, The Women's Health Centre, HCA Healthcare UK, London W1U 9QP, UK.
Anmol MalhotraThe London Breast Institute, The Women's Health Centre, HCA Healthcare UK, London W1U 9QP, UK.ORCID 0000-0002-9147-2323
Kinan MokbelThe London Breast Institute, The Women's Health Centre, HCA Healthcare UK, London W1U 9QP, UK.
Kefah MokbelThe London Breast Institute, The Women's Health Centre, HCA Healthcare UK, London W1U 9QP, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in neoadjuvant systemic therapy (NST) have significantly improved pathologic complete response rates in early breast cancer, challenging the role of axillary lymph node dissection in nose-positive patients. Targeted axillary dissection (TAD) integrates marked lymph node biopsy (MLNB) and tracer-guided sentinel lymph node biopsy (SLNB). The introduction of new wire-free localisation markers (LMs) has streamlined TAD and increased its adoption. The primary endpoints include the successful localisation and retrieval rates of LMs. The secondary endpoints include the pathological complete response (pCR), SLNB, and MLNB concordance, as well as false-negative rates. Seventeen studies encompassing 1358 TAD procedures in 1355 met the inclusion criteria. The localisation and retrieval rate of LMs were 97% and 99%. A concordance rate of 67% (95% CI: 64-70) between SLNB and MLNB was demonstrated. Notably, 49 days (range: 0-272) was the average LM deployment time to surgery. pCR was observed in 46% (95% CI: 43-49) of cases, with no significant procedure-related complications. Omitting MLNB or SLNB would have under-staged the axilla in 15.2% or 5.4% (

Indexed as

breast cancernode positivesystematic reviewtargeted axillary dissection

Identifiers

PMID38927878
PMCPMC11201777

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.