Evidence map›Paper›PMID 38927753›Full record

ArticleGenes2024

Correlation Analysis of Genetic Mutations and Galectin Levels in Breast Cancer Patients.

Ella G Markalunas, David H Arnold, Avery T Funkhouser, Julie C Martin, Michael Shtutman, W Jeffery Edenfield, Anna V Blenda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ella G MarkalunasDepartment of Public Health, Brown University, Providence, RI 02912, USA.ORCID 0009-0006-0554-8157
David H ArnoldDepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USA.
Avery T FunkhouserDepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USA.ORCID 0000-0001-9287-7683
Julie C MartinPrisma Health Cancer Institute, Prisma Health, Greenville, SC 29605, USA.ORCID 0000-0003-1829-4994
Michael ShtutmanDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC 29208, USA.ORCID 0000-0002-2458-3226
W Jeffery EdenfieldPrisma Health Cancer Institute, Prisma Health, Greenville, SC 29605, USA.ORCID 0000-0001-8232-2318
Anna V BlendaDepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USA.ORCID 0000-0001-7669-3120

Funding

Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RONINSON, IGOR B · 2014 to 2024
$25.2M
NIGMS NIH HHS P20 GM109091
6 · The paper itself

Abstract

Galectins are innate immune system regulators associated with disease progression in cancer. This paper aims to investigate the correlation between mutated cancer-critical genes and galectin levels in breast cancer patients to determine whether galectins and genetic profiles can be used as biomarkers for disease and potential therapy targets. Prisma Health Cancer Institute's Biorepository provided seventy-one breast cancer samples, including all four stages spanning the major molecular subtypes and histologies. Hotspot mutation statuses of cancer-critical genes were determined using multiplex PCR in tumor samples from the same patients by Precision Genetics and the University of South Carolina Functional Genomics Core Facility. The galectin-1, -3, and -9 levels in patients' sera were analyzed using Enzyme-linked Immunosorbent Assay (ELISA). An analysis was performed using JMP software to compare mean and median serum galectin levels between samples with and without specific cancer-critical genes, including pooled

Indexed as

Biomarkers, TumorBreast NeoplasmsGalectinsMutationAdultBlood ProteinsFemaleGalectin 1Galectin 3HumansMiddle AgedBiomarkers, TumorBlood ProteinsGalectin 1Galectin 3GalectinsLGALS1 protein, humanLGALS3 protein, humanLGALS9 protein, humanbiomarkerbreast cancergalectinsgenetic mutationmetastasis

Identifiers

PMID38927753
PMCPMC11203217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.