Evidence map›Paper›PMID 38927668›Full record

ArticleGenes2024

Prognostic Role of Human Leukocyte Antigen Alleles and Cytokine Single-Nucleotide Polymorphisms in Patients with Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitor Drugs.

Samuel Kinde Birru, Ilias Doxiadis, Rawleigh Howe, Tsehayneh Kelemu, Saifu Hailu Chala, Abdulaziz Sherif, Fisihatsion Tadesse, Aster Tsegaye, Amha Gebremedhin, Claudia Lehmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samuel Kinde BirruJosé Carreras Research Laboratory, Department of Hematology and Cell Therapy, Faculty of Medicine, University of Leipzig, Johannisallee 32A, 04103 Leipzig, Germany.
Ilias DoxiadisLaboratory for Transplantation Immunology, University Hospital Leipzig, Johannisallee 32, 04103 Leipzig, Germany.
Rawleigh HoweArmauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.
Tsehayneh KelemuCollege of Health Sciences, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Saifu Hailu ChalaCollege of Health Sciences, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Abdulaziz SherifCollege of Health Sciences, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.ORCID 0000-0002-0200-3024
Fisihatsion TadesseCollege of Health Sciences, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Aster TsegayeCollege of Health Sciences, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Amha GebremedhinCollege of Health Sciences, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Claudia LehmannLaboratory for Transplantation Immunology, University Hospital Leipzig, Johannisallee 32, 04103 Leipzig, Germany.ORCID 0000-0002-2791-764X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tyrosine kinase inhibitor (TKI) drugs have significantly improved chronic myeloid leukemia (CML) outcomes. Neopeptides from CML cells may induce specific immune responses, which are crucial for deep molecular (DMR) and treatment-free remission (TFR). In this study of Ethiopian patients with CML (n = 162), the HLA alleles and single-nucleotide polymorphisms of five cytokines revealed significant associations with clinical outcomes. Clinically unfavorable outcomes correlated with HLA alleles

Indexed as

CytokinesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveTyrosine Kinase InhibitorsAdolescentAdultAgedAllelesFemaleHLA AntigensHumansMaleMiddle AgedPolymorphism, Single NucleotidePrognosisCytokinesHLA AntigensTyrosine Kinase InhibitorsCMLcytokine polymorphismEthiopian HLA frequenciesIFN-γIL-10IL-6TGF-βTh17TNF-αTregtyrosine kinase inhibitor

Identifiers

PMID38927668
PMCPMC11203291

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.