Evidence map›Paper›PMID 38927659›Full record

ArticleGenes2024

Cosmic Whirl: Navigating the Comet Trail in DNA: H2AX Phosphorylation and the Enigma of Uncertain Significance Variants.

Sevdican Ustun Yilmaz, Nihat Bugra Agaoglu, Karin Manto, Meltem Muftuoglu, Ugur Özbek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sevdican Ustun YilmazDepartment of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Türkiye.ORCID 0000-0001-8349-3629
Nihat Bugra AgaogluDepartment of Medical Genetics, Umraniye Training and Research Hospital, University of Health Sciences, 34764 Istanbul, Türkiye.
Karin MantoDepartment of Genome Studies, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Türkiye.ORCID 0009-0006-9109-9799
Meltem MuftuogluDepartment of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Türkiye.ORCID 0000-0001-5372-4780
Ugur ÖzbekDepartment of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Türkiye.ORCID 0000-0001-5319-0547

Funding

Acıbadem University 2022/02-16.Scientific and Technological Research Council of Turkey 118C082
6 · The paper itself

Abstract

Pathogenic variations in the

Indexed as

BRCA2 ProteinBreast NeoplasmsHistonesComet AssayDNA Breaks, Double-StrandedDNA DamageFemaleHigh-Throughput Nucleotide SequencingHumansMutation, MissensePhosphorylationRetrospective StudiesBRCA2 ProteinBRCA2 protein, humanH2AX protein, humanHistonesBRCA2cometDNA Damagefunctional assayshereditary breast and ovarian cancer (HBOC) syndromeVUS classificationγH2AX

Identifiers

PMID38927659
PMCPMC11202575

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.