Evidence map›Paper›PMID 38927639›Full record

ArticleGenes2024

Placental Transcriptome Analysis in Connection with Low Litter Birth Weight Phenotype (LBWP) Sows.

Julia Linck Moroni, Stephen Tsoi, Irene I Wenger, Graham S Plastow, Michael K Dyck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julia Linck MoroniDepartment of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Stephen TsoiDepartment of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.ORCID 0000-0001-8762-7081
Irene I WengerDepartment of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Graham S PlastowDepartment of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.ORCID 0000-0002-3774-3110
Michael K DyckDepartment of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.ORCID 0000-0001-7894-7761

Funding

Natural Sciences and Engineering Research Council (NSERC) of Canada, Collaborative Research and Development Grant (CRDP) 462759
6 · The paper itself

Abstract

It is possible to identify sub-populations of sows in every pig herd that consistently give birth to low birth weight (BW) piglets, irrespective of the litter size. A previous study from our group demonstrated that placental development is a main factor affecting the litter birth weight phenotype (LBWP) in sows, thereby impacting the BW of entire litters, but the biological and molecular pathways behind this phenomenon are largely unknown. The aim of this study was to investigate the differential gene expression in placental tissues at day 30 of gestation between low LBWP (LLBWP) vs. high LBWP (HLBWP) sows from a purebred Large White maternal line. Using mRNA sequencing, we found 45 differentially expressed genes (DEGs) in placental tissues of LLBWP and HLBWP sows. Furthermore, (GO) enrichment of upregulated DEGs predicted that there were two biological processes significantly related to cornification and regulation of cell population proliferation. To better understand the molecular interaction between cell proliferation and cornification, we conducted transcriptional factor binding site (TFBS) prediction analysis. The results indicated that a highly significant TFBS was located at the 5' upstream of all four upregulated genes (

Indexed as

Birth WeightPlacentaAnimalsFemaleGene Expression ProfilingLitter SizePhenotypePregnancySwineTranscriptomelow litter birth weight phenotypemRNA-Seqplacentaporcinetranscriptional factor binding sitetranscriptome

Identifiers

PMID38927639
PMCPMC11203121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.