Evidence map›Paper›PMID 38927595›Full record

ArticleGenes2024

Lack of

Zirui Li, Zhiqiang Chen, Lianghao Zhao, Jiaqi Sun, Lin Yin, Yuwei Jiang, Xiaotong Shi, Ziye Song, Lu Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zirui LiCollege of Bioengineering, Henan University of Technology, 100 Lianhua Street, High-Tech Zone, Zhengzhou 450001, China.
Zhiqiang ChenCollege of Bioengineering, Henan University of Technology, 100 Lianhua Street, High-Tech Zone, Zhengzhou 450001, China.
Lianghao ZhaoCollege of Bioengineering, Henan University of Technology, 100 Lianhua Street, High-Tech Zone, Zhengzhou 450001, China.
Jiaqi SunCollege of Bioengineering, Henan University of Technology, 100 Lianhua Street, High-Tech Zone, Zhengzhou 450001, China.
Lin YinCollege of Bioengineering, Henan University of Technology, 100 Lianhua Street, High-Tech Zone, Zhengzhou 450001, China.
Yuwei JiangCollege of Bioengineering, Henan University of Technology, 100 Lianhua Street, High-Tech Zone, Zhengzhou 450001, China.
Xiaotong ShiCollege of Bioengineering, Henan University of Technology, 100 Lianhua Street, High-Tech Zone, Zhengzhou 450001, China.
Ziye SongCollege of Bioengineering, Henan University of Technology, 100 Lianhua Street, High-Tech Zone, Zhengzhou 450001, China.
Lu ZhangCollege of Bioengineering, Henan University of Technology, 100 Lianhua Street, High-Tech Zone, Zhengzhou 450001, China.

Funding

Double First-Class Discipline Construction Program of Henan University of Technology 0517-24410014Double First-Class Discipline Construction Program of Henan University of Technology HAUTSYL2023KC05Innovative Funds Plan of Henan University of Technology 2021ZKCJ16National Natural Science Foundation of China 32070742National Natural Science Foundation of Henan province 232300421030
6 · The paper itself

Abstract

Ageing has been identified as an independent risk factor for various diseases; however, the physiological basis and molecular changes related to ageing are still largely unknown. Here, we show that the level of APPL2, an adaptor protein, is significantly reduced in the major organs of aged mice. Knocking down APPL2 causes premature ageing of human umbilical vein endothelial cells (HUVECs). We find that a lack of

Indexed as

Adaptor Proteins, Signal TransducingAutophagyCaenorhabditis elegansCaenorhabditis elegans ProteinsLongevityAgingAging, PrematureAnimalsGTPase-Activating ProteinsHumansHuman Umbilical Vein Endothelial CellsMiceAdaptor Proteins, Signal TransducingCaenorhabditis elegans ProteinsGTPase-Activating Proteinsrho GTPase-activating proteinageingAPPL2autophagyC. eleganslifespanT04C9.1

Identifiers

PMID38927595
PMCPMC11202736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.