ArticleBiomedicines2024
Effects of Lithium Ions on tPA-Induced Hemorrhagic Transformation under Stroke.
Valentina A Babenko, Elmira I Yakupova, Irina B Pevzner, Alexey D Bocharnikov, Ljubava D Zorova, Kseniya S Fedulova, Oleg A Grebenchikov, Artem N Kuzovlev, Andrey V Grechko, Denis N Silachev and 2 more
Abstract read
In one paragraphArticle in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Valentina A BabenkoA.N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Elmira I YakupovaA.N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Irina B PevznerA.N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-5048-1234 Alexey D BocharnikovA.N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0009-0006-1359-4495 Ljubava D ZorovaA.N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Kseniya S FedulovaA.N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Oleg A GrebenchikovFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, Russia.
Artem N KuzovlevFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, Russia.
Andrey V GrechkoFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, Russia.
Denis N SilachevA.N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0003-0581-9755 Parvaneh Rahimi-MoghaddamDepartment of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.ORCID 0000-0001-9344-8143 Egor Y PlotnikovA.N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0003-2838-3704 Funding
Iran National Science Foundation (INSF) 99003982Russian Foundation for Basic Reserch 20-54-56028The Ministry of Science and Higher Education of the Russian Federation FGWS-2022-0001
6 · The paper itselfAbstract
Thrombolytic therapy with the tissue plasminogen activator (tPA) is a therapeutic option for acute ischemic stroke. However, this approach is subject to several limitations, particularly the increased risk of hemorrhagic transformation (HT). Lithium salts show neuroprotective effects in stroke, but their effects on HT mechanisms are still unknown. In our study, we use the models of photothrombosis (PT)-induced brain ischemia and oxygen-glucose deprivation (OGD) to investigate the effect of Li
Indexed as
hemorrhagic transformationlithium saltsoxygen-glucose deprivationphotothrombosistissue plasminogen activator
Identifiers
PMID38927532
PMCPMC11201972
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