Evidence map›Paper›PMID 38927525›Full record

ArticleBiomedicines2024

Effect of 5-Aminolevulinic Acid (5-ALA) in "ALADENT" Gel Formulation and Photodynamic Therapy (PDT) against Human Oral and Pancreatic Cancers.

Domenica Lucia D'Antonio, Simona Marchetti, Pamela Pignatelli, Samia Umme, Domenico De Bellis, Paola Lanuti, Adriano Piattelli, Maria Cristina Curia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Domenica Lucia D'AntonioDepartment of Medical, Oral and Biotechnological Sciences, "Gabriele d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0009-0000-6619-1530
Simona MarchettiDepartment of Medical, Oral and Biotechnological Sciences, "Gabriele d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Pamela PignatelliCOMDINAV DUE, Nave Cavour, Italian Navy, Stazione Navale Mar Grande, Viale Jonio, 74122 Taranto, Italy.ORCID 0000-0002-3023-7143
Samia UmmeDepartment of Medical, Oral and Biotechnological Sciences, "Gabriele d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Domenico De BellisCenter for Advanced Studies and Technology (CAST), "Gabriele d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-0953-1989
Paola LanutiCenter for Advanced Studies and Technology (CAST), "Gabriele d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-4197-9780
Adriano PiattelliSchool of Dentistry, Saint Camillus International University of Health and Medical Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.
Maria Cristina CuriaDepartment of Medical, Oral and Biotechnological Sciences, "Gabriele d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-4979-887X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous-cell and pancreatic carcinomas are aggressive cancers with a poor outcome. Photodynamic therapy (PDT) consists of the use of photosensitizer-induced cell and tissue damage that is activated by exposure to visible light. PDT selectively acts on cancer cells, which have an accumulation of photosensitizer superior to that of the normal surrounding tissues. 5-aminolevulinic acid (5-ALA) induces the production of protoporphyrin IX (PpIX), an endogenous photosensitizer activated in PDT. This study aimed to test the effect of a new gel containing 5%

Indexed as

5-aminolevulinic acidapoptosisCAL-27CAPAN-2cell cycleoral cancerpancreatic cancerphotodynamic therapyprotoporphyrinreactive oxygen species

Identifiers

PMID38927525
PMCPMC11201195

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.