Evidence map›Paper›PMID 38927523›Full record

ReviewBiomedicines2024

The Multifaceted Nature of Macrophages in Cardiovascular Disease.

Cindy X Li, Lixia Yue

Abstract readReview
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cindy X LiDepartment of Cell Biology, Pat and Jim Calhoun Cardiovascular Center, University of Connecticut Health Center, Farmington, CT 06030, USA.ORCID 0009-0006-8836-6737
Lixia YueDepartment of Cell Biology, Pat and Jim Calhoun Cardiovascular Center, University of Connecticut Health Center, Farmington, CT 06030, USA.ORCID 0000-0002-3558-091X

Funding

Calcium Signaling Mechanisms in Cardiac FibrogenesisR01HL171486 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Lixia Yue · 2024 to 2026
$2.0M
Transient Receptor Potential Melastatin 2 (TRPM2) in Ischemic StrokeR01NS131661 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Lixia Yue · 2024 to 2026
$1.3M
NHLBI NIH HHS R01 HL171486NIH HHS 1R01NS131661-01A1NIH HHS R01-NS131661
6 · The paper itself

Abstract

As the leading cause of mortality worldwide, cardiovascular disease (CVD) represents a variety of heart diseases and vascular disorders, including atherosclerosis, aneurysm, ischemic injury in the heart and brain, arrythmias, and heart failure. Macrophages, a diverse population of immune cells that can promote or suppress inflammation, have been increasingly recognized as a key regulator in various processes in both healthy and disease states. In healthy conditions, these cells promote the proper clearance of cellular debris, dead and dying cells, and provide a strong innate immune barrier to foreign pathogens. However, macrophages can play a detrimental role in the progression of disease as well, particularly those inflammatory in nature. This review will focus on the current knowledge regarding the role of macrophages in cardiovascular diseases.

Indexed as

atherosclerosiscardiovascular diseaselipid metabolismmacrophage-mediated inflammationmacrophages

Identifiers

PMID38927523
PMCPMC11201197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.