Evidence map›Paper›PMID 38927437›Full record

ReviewBiomedicines2024

Microbubble-Enhanced Focused Ultrasound for Infiltrating Gliomas.

Alexandra A Seas, Adarsha P Malla, Nima Sharifai, Jeffrey A Winkles, Graeme F Woodworth, Pavlos Anastasiadis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Recent Advances in Targeted Therapies for Adult Gliomas.Current neurology and neuroscience reports · 2026
    Review
  3. Review
  4. Review
  5. CAR-T cells immunotherapy in the treatment of glioblastoma.Cancer immunology, immunotherapy : CII · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexandra A SeasDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Adarsha P MallaDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Nima SharifaiMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, MD 21201, USA.ORCID 0000-0002-4992-3629
Jeffrey A WinklesDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-3305-1424
Graeme F WoodworthDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Pavlos AnastasiadisDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-0230-7925

Funding

Training Grant in Cancer BiologyT32CA154274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Toni M Antalis, CURT I CIVIN · 2011 to 2026
$6.8M
American Cancer Society IRG-18-160-16Department of Neurosurgery, University of Maryland School of Medicine Seed Funds n/aNCI NIH HHS 5T32CA154274-12NCI NIH HHS T32 CA154274
6 · The paper itself

Abstract

Infiltrating gliomas are challenging to treat, as the blood-brain barrier significantly impedes the success of therapeutic interventions. While some clinical trials for high-grade gliomas have shown promise, patient outcomes remain poor. Microbubble-enhanced focused ultrasound (MB-FUS) is a rapidly evolving technology with demonstrated safety and efficacy in opening the blood-brain barrier across various disease models, including infiltrating gliomas. Initially recognized for its role in augmenting drug delivery, the potential of MB-FUS to augment liquid biopsy and immunotherapy is gaining research momentum. In this review, we will highlight recent advancements in preclinical and clinical studies that utilize focused ultrasound to treat gliomas and discuss the potential future uses of image-guided precision therapy using focused ultrasound.

Indexed as

acoustic emissionsblood-brain barrierfocused ultrasoundglioblastomahigh-grade gliomasimmunotherapyinfiltrating gliomasmicrobubbles

Identifiers

PMID38927437
PMCPMC11200892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.