Evidence map›Paper›PMID 38927396›Full record

ArticleBiomedicines2024

Combination of Neovestitol and Vestitol Modifies the Profile of Periodontitis-Related Subgingival Multispecies Biofilm.

Tatiane Tiemi Macedo, Larissa Matias Malavazi, Gustavo Quilles Vargas, Francisco Jerfeson Dos Santos Gonçalves, Aline Paim de Abreu Paulo Gomes, Manuela Rocha Bueno, Lucas Daylor Aguiar da Silva, Luciene Cristina Figueiredo, Bruno Bueno-Silva

Abstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Frontiers in pharmacology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tatiane Tiemi MacedoDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil.
Larissa Matias MalavaziDepartamento de Biociências, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba 13414-903, SP, Brazil.ORCID 0009-0002-3552-5256
Gustavo Quilles VargasDepartamento de Biociências, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba 13414-903, SP, Brazil.
Francisco Jerfeson Dos Santos GonçalvesDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil.
Aline Paim de Abreu Paulo GomesDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil.
Manuela Rocha BuenoFaculdade São Leopoldo Mandic, Campinas 13045-775, SP, Brazil.ORCID 0000-0003-3073-039X
Lucas Daylor Aguiar da SilvaDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil.ORCID 0000-0003-3387-1710
Luciene Cristina FigueiredoDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil.
Bruno Bueno-SilvaDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil.ORCID 0000-0003-3275-5910

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior n/aFundação de Amparo à Pesquisa do Estado de São Paulo #2019/19691-0; # 2017/16377-7Fund to support teaching, research and extension (FAEPEX - Unicamp) #3364/23 and #2878/23Latin American Oral Health Association n/aNational Council for Scientific and Technological Development # 428984/2018-5
6 · The paper itself

Abstract

The aim of this study was to evaluate the effect of the combination of neovestitol-vestitol (CNV) compounds obtained from Brazilian red propolis on the microbiological profile of a mature multispecies subgingival biofilm. The biofilm with 32 bacterial species associated with periodontitis was formed for seven days using a Calgary device. Treatment with CNV (1600, 800, 400, and 200 μg/mL), amoxicillin (54 μg/mL), and vehicle control was performed for 24 h on the last day of biofilm formation. Biofilm metabolic activity and DNA-DNA hybridization (checkerboard) assays were performed. The groups treated with CNV 1600 and amoxicillin reduced 25 and 13 species, respectively, compared to the control vehicle treatment (

Indexed as

antimicrobialoral microorganismperiodontitisred propolis

Identifiers

PMID38927396
PMCPMC11200960

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.