Evidence map›Paper›PMID 38927256›Full record

ArticleBiology2024

Influence of Bilberry Extract on Neuronal Cell Toxicity.

Svenja König, Tamara Bakuradze, Sandy Jesser, Harshitha Ashoka Sreeja, Max J Carlsson, Jörg Fahrer, Stefan Kins, Elke Richling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Frontiers in nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Svenja KönigDivision of Human Biology and Neurobiology, Department of Biology, University of Kaiserslautern-Landau, Erwin-Schrödinger-Straße 13, D-67663 Kaiserslautern, Germany.ORCID 0009-0008-4045-5110
Tamara BakuradzeDivision of Food Chemistry and Toxicology, Department of Chemistry, University of Kaiserslautern-Landau, Erwin-Schrödinger-Straße 52, D-67663 Kaiserslautern, Germany.
Sandy JesserDivision of Food Chemistry and Toxicology, Department of Chemistry, University of Kaiserslautern-Landau, Erwin-Schrödinger-Straße 52, D-67663 Kaiserslautern, Germany.
Harshitha Ashoka SreejaDivision of Human Biology and Neurobiology, Department of Biology, University of Kaiserslautern-Landau, Erwin-Schrödinger-Straße 13, D-67663 Kaiserslautern, Germany.
Max J CarlssonDivision of Food Chemistry and Toxicology, Department of Chemistry, University of Kaiserslautern-Landau, Erwin-Schrödinger-Straße 52, D-67663 Kaiserslautern, Germany.
Jörg FahrerDivision of Food Chemistry and Toxicology, Department of Chemistry, University of Kaiserslautern-Landau, Erwin-Schrödinger-Straße 52, D-67663 Kaiserslautern, Germany.ORCID 0000-0001-5225-2718
Stefan KinsDivision of Human Biology and Neurobiology, Department of Biology, University of Kaiserslautern-Landau, Erwin-Schrödinger-Straße 13, D-67663 Kaiserslautern, Germany.ORCID 0000-0002-7231-4872
Elke RichlingDivision of Food Chemistry and Toxicology, Department of Chemistry, University of Kaiserslautern-Landau, Erwin-Schrödinger-Straße 52, D-67663 Kaiserslautern, Germany.ORCID 0000-0001-5746-8032

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased intake of dietary antioxidants such as anthocyanins, which are enriched in colourful fruits, is a promising alternative to reduce the risk of degenerative diseases such as Alzheimer's Disease (AD). Since Amyloid β (Aβ) is one of the key components contributing to AD pathology, probably by reactive oxygen species (ROS) induction, this study investigated the preventive effect of anthocyanin-rich bilberry extract (BE) and its anthocyanin fraction (ACN) on ROS generation and cell toxicity. The results showed a significant and concentration-dependent decrease in neuroblastoma cell (SH-SY5Y) viability by BE or ACN, whereas no cell toxicity was observed in HeLa cells. Incubation with BE and ACN for 24 h diminished the generation of induced ROS levels in SH-SY5Y and HeLa cells. In addition, low concentrations of BE (1-5 µg/mL) showed protective effects against Aβ-induced cytotoxicity in SH-SY5Y cells. In conclusion, our results suggest antioxidant and protective effects of BE and ACN, which could potentially be used to delay the course of neurodegenerative diseases such as AD. Further studies are needed to clarify the high potential of anthocyanins and their in vivo metabolites on neuronal function.

Indexed as

amyloid-betaanthocyaninscellular ROS levelcell viabilityneuroprotection

Identifiers

PMID38927256
PMCPMC11200780

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.