Evidence map›Paper›PMID 38927216›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Synergistic Combination of Aztreonam and Ceftazidime-Avibactam-A Promising Defense Strategy against OXA-48 + NDM

Ioana Miriana Cismaru, Maria Cristina Văcăroiu, Elif Soium, Tiberiu Holban, Adelina Maria Radu, Violeta Melinte, Valeriu Gheorghiță

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ioana Miriana CismaruAgrippa Ionescu Clinical Emergency Hospital, 011356 Bucharest, Romania.
Maria Cristina VăcăroiuAgrippa Ionescu Clinical Emergency Hospital, 011356 Bucharest, Romania.ORCID 0009-0007-4163-8085
Elif SoiumAgrippa Ionescu Clinical Emergency Hospital, 011356 Bucharest, Romania.
Tiberiu HolbanAgrippa Ionescu Clinical Emergency Hospital, 011356 Bucharest, Romania.
Adelina Maria RaduAgrippa Ionescu Clinical Emergency Hospital, 011356 Bucharest, Romania.
Violeta MelinteAgrippa Ionescu Clinical Emergency Hospital, 011356 Bucharest, Romania.
Valeriu GheorghițăAgrippa Ionescu Clinical Emergency Hospital, 011356 Bucharest, Romania.ORCID 0000-0002-7819-5464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the increasing burden of carbapenem-resistant

objectivesWe reviewed the clinical and microbiological outcomes of seven patients treated at the "Agrippa Ionescu" Clinical Emergency Hospital between October 2023 and January 2024, aiming to demonstrate the synergistic activity of the ceftazidime-avibactam (C/A) plus aztreonam (ATM) combination against the co-producers of MATERIAL AND

methodsSeven CR-Kp with

resultsWith a mean of nine days of treatment with the synergistic combination C/A + ATM, all patients achieved clinical recovery, and five achieved microbiological recovery.

conclusionsWith the emerging co-occurrence of

Indexed as

aztreonamblaNDMblaOXA-48carbapenem-resistant Klebsiella pneumoniaeceftazidime–avibactamsynergism

Identifiers

PMID38927216
PMCPMC11201077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.