Evidence map›Paper›PMID 38927129›Full record

ArticleBiomolecules2024

Gasdermin D Inhibitor Necrosulfonamide Alleviates Angiotensin II-Induced Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice.

Jia Guo, Qing Zhang, Zhidong Li, Min Qin, Jinyun Shi, Yan Wang, Wenjia Ai, Junjie Ju, Makoto Samura, Philip S Tsao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jia GuoDepartment of Cardiovascular Medicine, First Hospital Shanxi Medical University, Taiyuan 030001, Shanxi, China.
Qing ZhangDepartment of Cardiovascular Medicine, First Hospital Shanxi Medical University, Taiyuan 030001, Shanxi, China.
Zhidong LiDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, Shanxi, China.
Min QinDepartment of Cardiovascular Medicine, First Hospital Shanxi Medical University, Taiyuan 030001, Shanxi, China.
Jinyun ShiDepartment of Cardiovascular Medicine, First Hospital Shanxi Medical University, Taiyuan 030001, Shanxi, China.
Yan WangInstitute of Medical Innovation and Research, Peking University Third Hospital, Beijing 100191, China.
Wenjia AiDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-5375-4557
Junjie JuDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Makoto SamuraDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Philip S TsaoCardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Baohui XuDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-2857-7464

Funding

Abroad Return Scholar Fund of Shanxi Province 2021-159Central Funds Guiding the Local Science and Technology Development Jincaijiao-2020165-Z135050009017).National Natural Science Foundation of China 81600256 and 82001248
6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is a chronic aortic disease that lacks effective pharmacological therapies. This study was performed to determine the influence of treatment with the gasdermin D inhibitor necrosulfonamide on experimental AAAs. AAAs were induced in male apolipoprotein E-deficient mice by subcutaneous angiotensin II infusion (1000 ng/kg body weight/min), with daily administration of necrosulfonamide (5 mg/kg body weight) or vehicle starting 3 days prior to angiotensin II infusion for 30 days. Necrosulfonamide treatment remarkably suppressed AAA enlargement, as indicated by reduced suprarenal maximal external diameter and surface area, and lowered the incidence and reduced the severity of experimental AAAs. Histologically, necrosulfonamide treatment attenuated medial elastin breaks, smooth muscle cell depletion, and aortic wall collagen deposition. Macrophages, CD4

Indexed as

Angiotensin IIAortic Aneurysm, AbdominalApolipoproteins ESulfonamidesAnimalsDisease Models, AnimalGasderminsIndolesMacrophagesMaleMiceMice, Inbred C57BLMice, Knockout, ApoEPhosphate-Binding ProteinsAngiotensin IIApolipoproteins EGasderminsGsdmd protein, mouseIndolesPhosphate-Binding ProteinsSulfonamidesabdominal aortic aneurysmsgasdermin Dnecrosulfonamide

Identifiers

PMID38927129
PMCPMC11201507

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.