Evidence map›Paper›PMID 38927036›Full record

ArticleBiomolecules2024

TRPA1 Covalent Ligand JT010 Modifies T Lymphocyte Activation.

Katalin Szabó, Géza Makkai, János Konkoly, Viktória Kormos, Balázs Gaszner, Tímea Berki, Erika Pintér

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Sesquiterpene Lactone Derivatives ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Article
  3. TRPA1 for Butterfly Eyespot Formation.International journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katalin SzabóInstitute of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.ORCID 0000-0001-6569-3862
Géza MakkaiNano-Bio-Imaging Core Facility, University of Pécs Medical School, H-7624 Pécs, Hungary.ORCID 0000-0001-5579-167X
János KonkolyInstitute of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.
Viktória KormosInstitute of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.ORCID 0000-0002-3360-2425
Balázs GasznerResearch Group for Mood Disorders, Department of Anatomy, University of Pécs Medical School, H-7624 Pécs, Hungary.ORCID 0000-0003-2830-2732
Tímea BerkiDepartment of Immunology and Biotechnology, University of Pécs Clinical Center, H-7624 Pécs, Hungary.
Erika PintérInstitute of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Hungary.ORCID 0000-0001-9898-632X

Funding

Ministry for Innovation and Technology in Hungary Hungarian Brain Research Program (NAP-3) HUN-RENMinistry for Innovation and Technology in Hungary NKFI-146117Ministry for Innovation and Technology in Hungary TKP2021-EGA-16National Research, Development and Innovation Fund ÚNKP-23-4-I-PTE-1853National Research, Development and Innovation Fund ÚNKP-23-5-PTE-1991New National Excellence Program of the Ministry for Culture ÚNKP-23-4New National Excellence Program of the Ministry for Innovation and Technology BO/00750/22/5Research grant of Medical School, University of Pécs KA-2022-29
6 · The paper itself

Abstract

Transient Receptor Potential Ankyrin 1 (TRPA1) is a non-selective cation channel involved in sensitivity to a plethora of irritating agents and endogenous mediators of oxidative stress. TRPA1 influences neuroinflammation and macrophage and lymphocyte functions, but its role is controversial in immune cells. We reported earlier a detectable, but orders-of-magnitude-lower level of

Indexed as

Lymphocyte ActivationTRPA1 Cation ChannelAcetanilidesAnimalsCalciumCalcium SignalingCD4-Positive T-LymphocytesLigandsMaleMiceMice, Inbred C57BLReceptors, Antigen, T-CellRNA, MessengerT-LymphocytesAcetanilidesCalciumLigandsReceptors, Antigen, T-CellRNA, MessengerTRPA1 Cation ChannelTrpa1 protein, mouseB cellsCD14+ cellsCD4+ cellsdual RNAscope® ISH-IF techniqueflow cytometryintracellular Ca2+JT010lymphocytesmonocytesTcR activationTRPA1

Identifiers

PMID38927036
PMCPMC11202300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.