Evidence map›Paper›PMID 38927010›Full record

ArticleBiomolecules2024

Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids.

Bokai Zhu, Xiaoyang Zhu, Michael G Borland, Douglas H Ralph, Christopher R Chiaro, Kristopher W Krausz, James M Ntambi, Adam B Glick, Andrew D Patterson, Gary H Perdew and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Mechanism of PPARα agonist in alopecia areata.American journal of translational research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bokai ZhuDepartment of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0003-0827-5757
Xiaoyang ZhuDepartment of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0001-7796-835X
Michael G BorlandDepartment of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Douglas H RalphDepartment of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Christopher R ChiaroDepartment of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Kristopher W KrauszLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
James M NtambiDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-9784-9550
Adam B GlickDepartment of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0003-2073-0070
Gary H PerdewDepartment of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Jeffrey M PetersDepartment of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.

Funding

Activation of the Ah receptor and epithelial integrityR35ES028244 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PERDEW, GARY H. · 2017 to 2024
$6.2M
Unique targeting of PPARβ/δ regulation for cancer prevention and therapyR01CA239256 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW, PETERS, JEFFREY M · 2020 to 2024
$3.2M
Modulation of skin cancer by PPARBeta/deltaR01CA124533 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI PETERS, JEFFREY M · 2007 to 2017
$2.4M
NCI NIH HHS R01 CA124533NCI NIH HHS R01 CA239256NIEHS NIH HHS R35 ES028244
6 · The paper itself

Abstract

Nuclear hormone receptors exist in dynamic equilibrium between transcriptionally active and inactive complexes dependent on interactions with ligands, proteins, and chromatin. The present studies examined the hypothesis that endogenous ligands activate peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in keratinocytes. The phorbol ester treatment or HRAS infection of primary keratinocytes increased fatty acids that were associated with enhanced PPARβ/δ activity. Fatty acids caused PPARβ/δ-dependent increases in chromatin occupancy and the expression of angiopoietin-like protein 4 (

Indexed as

KeratinocytesPPAR-betaPPAR deltaStearoyl-CoA DesaturaseAngiopoietin-Like Protein 4AnimalsFatty AcidsFatty Acids, MonounsaturatedHumansMiceOleic AcidProto-Oncogene Proteins p21(ras)Skin NeoplasmsAngiopoietin-Like Protein 4Fatty AcidsFatty Acids, MonounsaturatedHras protein, mouseOleic Acidpalmitoleic acidPPAR-betaPPAR deltaProto-Oncogene Proteins p21(ras)Scd1 protein, mouseStearoyl-CoA Desaturasecell cyclefatty acidsligandsperoxisome proliferator-activated receptorUVB-induced non-melanoma skin cancer

Identifiers

PMID38927010
PMCPMC11201440

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.