Evidence map›Paper›PMID 38926770›Full record

ArticleTrials2024

Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: a pragmatic randomised triaL (VITAL).

Joyce Yeung, Shaman Jhanji, John Braun, Janet Dunn, Lucy Eggleston, Samuel Frempong, Louise Hiller, Claire Jacques, Monica Jefford, James Mason and 5 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Joyce Yeung *Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK. j.yeung.4@warwick.ac.uk.ORCID http://orcid.org/0000-0003-2950-4758
Shaman Jhanji *The Royal Marsden NHS Foundation Trust, London, UK.
John BraunThe Royal Marsden NHS Foundation Trust, London, UK.
Janet DunnWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Lucy EgglestonWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Samuel FrempongCentre for Health Economics at Warwick, Warwick Medical School, University of Warwick, Coventry, UK.
Louise HillerWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Claire JacquesWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Monica JeffordThe Royal Marsden NHS Foundation Trust, London, UK.
James MasonCentre for Health Economics at Warwick, Warwick Medical School, University of Warwick, Coventry, UK.
Ramani MoonesingheUniversity College London, London, UK.
Rupert PearseQueen Mary University of London, London, UK.
Benjamin ShelleySchool of Medicine, University of Glasgow, Glasgow, UK.
Cecilia VindrolaUniversity College London, London, UK.
VITAL trial team

Funding

Health Technology Assessment Programme NIHR130573
6 · The paper itself

Abstract

backgroundImproving outcomes after surgery is a major public health research priority for patients, clinicians and the NHS. The greatest burden of perioperative complications, mortality and healthcare costs lies amongst the population of patients aged over 50 years who undergo major non-cardiac surgery. The Volatile vs Total Intravenous Anaesthesia for major non-cardiac surgery (VITAL) trial specifically examines the effect of anaesthetic technique on key patient outcomes: quality of recovery after surgery (quality of recovery after anaesthesia, patient satisfaction and major post-operative complications), survival and patient safety.

methodsA multi-centre pragmatic efficient randomised trial with health economic evaluation comparing total intravenous anaesthesia with volatile-based anaesthesia in adults (aged 50 and over) undergoing elective major non-cardiac surgery under general anaesthesia. DISCUSSION: Given the very large number of patients exposed to general anaesthesia every year, even small differences in outcome between the two techniques could result in substantial excess harm. Results from the VITAL trial will ensure patients can benefit from the very safest anaesthesia care, promoting an early return home, reducing healthcare costs and maximising the health benefits of surgical treatments.

trial registrationISRCTN62903453. September 09, 2021.

Indexed as

Anesthesia, IntravenousPatient SatisfactionPostoperative ComplicationsAgedAnesthesia, GeneralAnesthesia, InhalationAnesthesia Recovery PeriodElective Surgical ProceduresFemaleHealth Care CostsHumansMaleMiddle AgedMulticenter Studies as TopicPragmatic Clinical Trials as TopicTreatment OutcomeGeneral anaesthesiaMajor surgeryPatient outcomesPost-operative complicationsRandomised controlled trial

Identifiers

PMID38926770
PMCPMC11210167

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.