Observational studyCardiovascular diabetology2024
U-shaped association between triglyceride-glucose index and all-cause mortality among critically ill pediatrics: a population-based retrospective cohort study.
Observational study in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Association between triglyceride-glucose index and elevated blood pressure among U.S. adolescents aged 12-17.Pediatric research · 2026Article
- C-reactive protein-triglyceride glucose index and its dynamic trajectories on all-cause mortality in critically ill children: a longitudinal, retrospective cohort study.Pediatric research · 2026Article
- Prognostic Significance of Triglyceride Glucose Index in Intracerebral Hemorrhage.Medical sciences (Basel, Switzerland) · 2026Article
- Combining triglyceride‑glucose index and novel anthropometric measures to predict mortality risk in patients with T2DM: a prospective cohort study.BMC endocrine disorders · 2026Article
- Triglyceride-Glucose Index and 30-day mortality in pediatric sepsis: a retrospective cohort study based on PIC database.Frontiers in pediatrics · 2026Article
- L-shaped association between fibrinogen to serum albumin ratio and all-cause mortality among critically ill children: a retrospective cohort study.BMC pediatrics · 2025Article
- Evaluative performance of TyG-ABSI versus traditional indices in relation to cardiovascular disease and mortality: evidence from the U.S. NHANES.Cardiovascular diabetology · 2025Article
- Associations between triglyceride-glucose body mass index and all-cause mortality in ICU patients with sepsis and acute heart failure.BMC cardiovascular disorders · 2025Article
- Associations of the triglyceride-glucose index with mortality mediated by blood urea nitrogen among critically ill patients: a cohort study.Scientific reports · 2025Article
- The association between the triglyceride‒glucose index and short-term mortality in ICU patients with sepsis-associated acute kidney injury.BMC infectious diseases · 2025Article
- Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database.Scientific reports · 2025Observational
- Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts.Cardiovascular diabetology · 2025Article
- U-shaped association between triglyceride-glucose index and acute kidney injury in critically ill children with cardiac diseases.Frontiers in endocrinology · 2025Article
- Prognostic value of the lactate dehydrogenase-to-albumin ratio for predicting mortality in critically ill pediatric patients: a retrospective cohort study.Frontiers in pediatrics · 2025Article
- L-shaped association between triglyceride-glucose body mass index and short-term mortality in ICU patients with sepsis-associated acute kidney injury.Frontiers in medicine · 2024Article
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10 authors.
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Abstract
backgroundPrevious studies have shown that an elevated triglyceride-glucose (TyG) index was associated with all-cause mortality in both general adult individuals and critically ill adult patients. However, the relationship between the TyG index and clinical prognosis in pediatric patients admitted to the intensive care unit (ICU) remains unknown. We aimed to investigate the association of the TyG index with in-hospital all-cause mortality in critically ill pediatric patients.
methodsA total of 5706 patients in the Pediatric Intensive Care database were enrolled in this study. The primary outcome was 30-day in-hospital all-cause mortality, and secondary outcome was 30-day in-ICU all-cause mortality. The restricted cubic spline (RCS) curves and two-piecewise multivariate Cox hazard regression models were performed to explore the relationship between the TyG index and outcomes.
resultsThe median age of the study population was 20.5 [interquartile range (IQR): 4.8, 63.0] months, and 3269 (57.3%) of the patients were male. The mean TyG index level was 8.6 ± 0.7. A total of 244 (4.3%) patients died within 30 days of hospitalization during a median follow-up of 11 [7, 18] days, and 236 (4.1%) patients died in ICU within 30 days of hospitalization during a median follow-up of 6 [3, 11] days. The RCS curves indicated a U-shape association between the TyG index and 30-day in-hospital and in-ICU all-cause mortality (both P values for non-linear < 0.001). The risk of 30-day in-hospital all-cause mortality was negatively correlated with the TyG index until it bottoms out at 8.6 (adjusted hazard ratio [HR], 0.72, 95% confidence interval [CI] 0.55-0.93). However, when the TyG index was higher than 8.6, the risk of primary outcome increased significantly (adjusted HR, 1.51, 95% CI 1.16-1.96]). For 30-day in-ICU all-cause mortality, we also found a similar relationship (TyG < 8.6: adjusted HR, 0.75, 95% CI 0.57-0.98; TyG ≥ 8.6: adjusted HR, 1.42, 95% CI 1.08-1.85). Those results were consistent in subgroups and various sensitivity analysis.
conclusionsOur study showed that the association between the TyG index and 30-day in-hospital and in-ICU all-cause mortality was nonlinear U-shaped, with a cutoff point at the TyG index of 8.6 in critically ill pediatric patients. Our findings suggest that the TyG index may be a novel and important factor for the short-term clinical prognosis in pediatric patients.
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