Evidence map›Paper›PMID 38926610›Full record

ArticleScientific reports2024

The impact of telomere length on the risk of idiopathic normal pressure hydrocephalus: a bidirectional Mendelian randomization study.

Zhihao Wang, Mingrong Zuo, Wenhao Li, Siliang Chen, Yunbo Yuan, Yuze He, Yuan Yang, Qing Mao, Yanhui Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next.Movement disorders : official journal of the Movement Disorder Society · 2025
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhihao Wang *Department of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
Mingrong Zuo *Department of Pediatric Neurosurgery, West China Women's and Children's Hospital: Sichuan University West China Second University Hospital, Chengdu, 610041, China.
Wenhao LiDepartment of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
Siliang ChenDepartment of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
Yunbo YuanDepartment of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
Yuze HeDepartment of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
Yuan YangDepartment of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
Qing MaoDepartment of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China.
Yanhui LiuDepartment of Neurosurgery, West China Hospital, Sichuan University, No 37 Guoxue Avenue, Chengdu, 610041, Sichuan, China. liuyh@scu.edu.cn.ORCID 0000-0002-3722-3334

Funding

the Sichuan Science and Technology Program 2023YFG0127the Sichuan Science and Technology Program 2023YFQ0002
6 · The paper itself

Abstract

Idiopathic normal pressure hydrocephalus (iNPH) affects mainly aged populations. The gradual shortening of telomere length (TL) is one of the hallmarks of aging. Whereas the genetic contribution of TL to the iNPH is incompletely understood. We aimed to investigate the causal relationship between TL and iNPH through the Mendelian randomization (MR) analysis. We respectively obtained 186 qualified single nucleotide polymorphisms (SNPs) of TL and 20 eligible SNPs of iNPH for MR analysis. The result of MR analysis showed that genetically predicted longer TL was significantly associated with a reduced odd of iNPH (odds ratio [OR] = 0.634 95% Confidence interval [CI] 0.447-0.899, p = 0.011). The causal association remained consistent in multivariable MR (OR = 0.530 95% CI 0.327-0.860, p = 0.010). However, there was no evidence that the iNPH was causally associated with the TL (OR = 1.000 95% CI 0.996-1.004, p = 0.955). Our study reveals a potential genetic contribution of TL to the etiology of iNPH, that is a genetically predicted increased TL might be associated with a reduced risk of iNPH.

Indexed as

Hydrocephalus, Normal PressureMendelian Randomization AnalysisPolymorphism, Single NucleotideAgedGenetic Predisposition to DiseaseHumansMaleRisk FactorsTelomereTelomere HomeostasisCausalityIdiopathic normal pressure hydrocephalusMendelian randomizationTelomere length

Identifiers

PMID38926610
PMCPMC11208170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.