ArticleNature2024
Brain Chimeroids reveal individual susceptibility to neurotoxic triggers.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience.Advanced healthcare materials · 2026Pooled it
- Bringing cellular clarity to the cortical component of ALS with a high-density multi-electrode array system.The FEBS journal · 2026Review
- Organization from cell to tissue derived delivery systems for immunotherapy.Materials today. Bio · 2026Article
- Tutorial: interrogating biology using organoid technologies.Nature protocols · 2026Review
- Brain organoids in Alzheimer disease and related tauopathies: Challenges and opportunities for translational readiness.Stem cell reports · 2026Review
- Article
- Induced pluripotent stem cells from discovery to translation.Nature medicine · 2026Review
- Drug screen and machine learning predict neuroprotective agents in a preclinical human model of childhood dementia.Nature communications · 2026Article
- Modeling Epilepsies with Human Brain Organoids: Recent Advances and Ongoing Challenges.Epilepsy currents · 2026Review
- CellBouncer, a unified toolkit for single-cell demultiplexing and ambient RNA analysis, reveals hominid mitochondrial incompatibilities.Cell genomics · 2026Article
- Convergence of schizophrenia risk genes on CALN1 disrupts human forebrain development and drives core psychotic behaviors including hallucination-like perception.BMC medicine · 2026Article
- Ethics and Regulation of Human Brain Organoid Research: Recommendations from the Asia Pacific Neuroethics Working Group.Asian bioethics review · 2026Article
- Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis.Journal of neurochemistry · 2026Review
- Advances and applications of brain organoids in central nervous system disorders: Bridging the gap from laboratory to clinic.Neural regeneration research · 2026Article
- Accurate trajectory inference in time-series spatial transcriptomics with structurally-constrained optimal transport.Nature communications · 2026Article
- Three-dimensional patient-derived cell models represent an emerging frontier in the study of neurodegenerative diseases.Neural regeneration research · 2026Article
- Intrinsic coordination of dynamic molecular signatures shape the human prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.Nature neuroscience · 2026Article
- Translating Pharmacology from Animal Models to Organoids: Advancing Predictive Human Biology in Drug Discovery.Stem cell reviews and reports · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Noelia Antón-Bolaños *Department of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-6590-4316
Irene Faravelli *Department of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Tyler FaitsDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-7524-6166
Sophia AndreadisDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Rahel KastliDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Sebastiano TrattaroDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Xian AdiconisStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Anqi WeiDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Abhishek Sampath KumarDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-7918-6706
Daniela J Di BellaDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-6141-3704
Matthew TegtmeyerDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-9032-8207
Ralda NehmeDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-7215-3311
Joshua Z LevinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-0170-3598
Aviv RegevBroad Institute of MIT and Harvard, Boston, MA, USA.
Paola ArlottaDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA. paola_arlotta@harvard.edu.ORCID 0000-0003-2184-2277
Funding
Genetic neuroscience: How human genes and alleles shape neuronal phenotypesU01MH115727 · NIMH · BROAD INSTITUTE, INC. · PI ARLOTTA, PAOLA, BABADI, MEHRTASH · 2017 to 2021
$20.8MRes Support CoreP50MH094271 · NIMH · HARVARD UNIVERSITY · PI HENSCH, TAKAO K · 2011 to 2022
$18.6MModeling ASD-linked genetic mutations in 3D human brain organoidsR01MH112940 · NIMH · HARVARD UNIVERSITY · PI Paola Arlotta · 2018 to 2026
$5.2MUnraveling the Genetic Programs Engaged in ASD Neurons Through Coupled Transcriptomic and Phenotypic ReadoutsR01MH128366 · NIMH · BROAD INSTITUTE, INC. · PI Samouil Farhi, Ralda Nehme · 2022 to 2026
$3.7MHigh throughput assaying of circuit activity and connectivity in brain organoidsRF1MH123977 · NIMH · HARVARD UNIVERSITY · PI ARLOTTA, PAOLA, BOYDEN, EDWARD S. · 2020 to 2020
$2.5MNIMH NIH HHS P50 MH094271NIMH NIH HHS R01 MH112940NIMH NIH HHS R01 MH128366NIMH NIH HHS RF1 MH123977NIMH NIH HHS U01 MH115727
Abstract
Interindividual genetic variation affects the susceptibility to and progression of many diseases
Indexed as
Cerebral CortexChimeraGenetic Predisposition to DiseaseNeurotoxinsOrganoidsCell LineageEthanolFemaleGenetic VariationHumansMaleNeural Stem CellsPhenotypePluripotent Stem CellsTissue DonorsValproic AcidEthanolNeurotoxinsValproic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.