Evidence map›Paper›PMID 38926571›Full record

ArticleNature2024

An intermediate Rb-E2F activity state safeguards proliferation commitment.

Yumi Konagaya, David Rosenthal, Nalin Ratnayeke, Yilin Fan, Tobias Meyer

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Next-generation CDK inhibitors in HR+/HER2- breast cancer.The Journal of clinical investigation · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. CDC7 and APC/CNature communications · 2026
    Article
  6. Article
  7. Article
  8. Chromatin association promotes UBR5-mediated degradation of Rb.bioRxiv : the preprint server for biology · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Tumor necrosis factor α-induced endoplasmic reticulum stress promotes airway smooth muscle cell proliferation.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yumi KonagayaDepartment of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA. yumi.konagaya@riken.jp.ORCID 0000-0002-6631-2002
David RosenthalDepartment of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA.
Nalin RatnayekeDepartment of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA.
Yilin FanDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Tobias MeyerDepartment of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA. tom4003@med.cornell.edu.ORCID 0000-0003-4339-3804

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Cell Signaling and Cell DecisionsR35GM127026 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TOBIAS MEYER · 2018 to 2026
$8.5M
Noncanonical E2F Regulation in the Neuronal DNA Damage ResponseF30MH132311 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROSENTHAL, DAVID LEON · 2023 to 2025
$161k
NIGMS NIH HHS R35 GM127026NIGMS NIH HHS T32 GM007739NIMH NIH HHS F30 MH132311
6 · The paper itself

Abstract

Tissue repair, immune defence and cancer progression rely on a vital cellular decision between quiescence and proliferation

Indexed as

Cell ProliferationE2F Transcription FactorsRetinoblastoma ProteinCell LineChromatinCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Feedback, PhysiologicalG1 PhaseHumansPhosphoproteinsPhosphorylationSingle-Cell AnalysisCDK2 protein, humanCDK4 protein, humanCDK6 protein, humanChromatinCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6E2F Transcription FactorsPhosphoproteinsRetinoblastoma Protein

Identifiers

PMID38926571
PMCPMC11236703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.