Evidence map›Paper›PMID 38926504›Full record

ArticleScientific reports2024

Early environmental predictors for attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and their co-occurrence: The prospective ABIS-Study.

Andrea Lebeña, Åshild Faresjö, Michael P Jones, Felicia Bengtsson, Tomas Faresjö, Johnny Ludvigsson

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. AI and neuroimaging in autism spectrum disorder: advances in diagnosis, methodological challenges and future directions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Patterns of Early Development in Children with ADHD.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026
    Article
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  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea LebeñaDivision of Pediatrics, Department of Biomedical and Clinical Sciences, Linköping University, US Campus, Building 511 (14, 09B), 581 83, Linköping, Sweden. andrea.lebena@liu.se.
Åshild FaresjöDepartment of Medicine and Health, Community Medicine, Linköping University, Linköping, Sweden.
Michael P JonesSchool of Psychological Sciences, Macquarie University, North Ryde, NSW, Australia.
Felicia BengtssonDepartment of Medicine and Health, Community Medicine, Linköping University, Linköping, Sweden.
Tomas FaresjöDepartment of Medicine and Health, Community Medicine, Linköping University, Linköping, Sweden.
Johnny LudvigssonDivision of Pediatrics, Department of Biomedical and Clinical Sciences, Linköping University, US Campus, Building 511 (14, 09B), 581 83, Linköping, Sweden.

Funding

Swedish Council for Working Life and Social Research FAS2004-1775Swedish Research Council K2005-72X-11242-11AWallenberg Foundation K 98-99D-12813-01A
6 · The paper itself

Abstract

ADHD and ASD are highly heritable and show a high co-occurrence and persistence into adulthood. This study aimed to identify pre and perinatal risk factors, and early psychosocial exposures related to later diagnosis of ADHD, ASD, and their co-occurrence. 16,365 children born 1997-1999 and their families, involved in the prospective population-based ABIS study (All Babies in Southeast Sweden), were included in this sub-study. Pre and perinatal factors and early environmental psychosocial exposures were collected from parental-questionnaires at birth and 1-year follow-up. Diagnoses from birth up to 23 years of age were obtained from the Swedish National Diagnosis Register in 2020. The cumulative incidence of ADHD, ASD, and their co-occurrence in the ABIS-cohort Study were 4.6%, 1.7%, and 1.1%, respectively. Being male was associated with an increased risk for ADHD, ASD, and their co-occurrence (aOR 1.30, 1.56, and 1.91, respectively), while higher household income reduced it (aOR 0.82, 0.73, and 0.64). Serious life events during pregnancy (aOR 1.40) and maternal smoking (aOR 1.51) increased the risk of ADHD, while older maternal age (aOR 0.96), higher parental education (aOR 0.72 maternal and aOR 0.74 paternal) and longer exclusive breastfeeding (aOR 0.72) reduced it. Non-Swedish paternal nationality (aOR 0.40) and higher maternal education (aOR 0.74) were associated with a lower risk of ASD, while a family history of autoimmune diseases increased the risk of the co-occurrence of both disorders (aOR 1.62). Obtained results suggest that the etiology of ADHD, ASD, and their co-occurrence is independently associated with environmental psychosocial predictors. The co-occurrence seems to overlap the etiology of ADHD, in which psychosocial determinants have a larger role, however, it is also independently influenced by a family history of autoimmune diseases.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderAdolescentAdultChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMalePregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsABISADHDASDCo-occurrenceEnvironmental exposureEpidemiologyEtiologyPsychosocial vulnerability

Identifiers

PMID38926504
PMCPMC11208583

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.