Evidence map›Paper›PMID 38926492›Full record

ArticleThe Journal of antibiotics2024

Geministatins: new depside antibiotics from the fungus Austroacremonium gemini.

Andrew Crombie, John A Kalaitzis, Rachel Chen, Daniel Vuong, Alastair E Lacey, Ernest Lacey, Roger G Shivas, Yu Pei Tan, Nicolau Sbaraini, Yit-Heng Chooi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antibiotics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Heterologous expression of anChemical science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrew CrombieMicrobial Screening Technologies, Smithfield, NSW, 2164, Australia.
John A KalaitzisSchool of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
Rachel ChenMicrobial Screening Technologies, Smithfield, NSW, 2164, Australia.
Daniel VuongMicrobial Screening Technologies, Smithfield, NSW, 2164, Australia.
Alastair E LaceyMicrobial Screening Technologies, Smithfield, NSW, 2164, Australia.
Ernest LaceyMicrobial Screening Technologies, Smithfield, NSW, 2164, Australia.ORCID 0000-0002-5387-2721
Roger G ShivasDepartment of Agriculture and Fisheries, Plant Pathology Herbarium, Dutton Park, QLD, 4102, Australia.
Yu Pei TanDepartment of Agriculture and Fisheries, Plant Pathology Herbarium, Dutton Park, QLD, 4102, Australia.
Nicolau SbarainiSchool of Molecular Sciences, The University of Western Australia, Perth, WA, 6009, Australia.
Yit-Heng ChooiSchool of Molecular Sciences, The University of Western Australia, Perth, WA, 6009, Australia.ORCID 0000-0001-7719-7524
Andrew M PiggottSchool of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia. andrew.piggott@mq.edu.au.ORCID 0000-0002-5308-5314

Funding

Department of Education and Training | Australian Research Council (ARC) LP210100458Department of Industry, Innovation and Science, Australian Government (Department of Industry, Innovation and Science) CRCPFIVE000119
6 · The paper itself

Abstract

Two new depside antibiotics, geministatins A (1) and B (2), were isolated from the fungus Austroacremonium gemini MST-FP2131 (Sordariomycetes, Ascomycota), which was recovered from rotting wood in the wet tropics of northern Australia. The structures of the geministatins were elucidated by detailed spectroscopic analysis, chemical degradation and comparison with literature values. Chemical degradation of 1 and 2 yielded three new analogues, geministatins C-E (3-5), as well as a previously reported compound dehydromerulinic acid A (6). Compounds 1, 2 and 6 exhibited antibacterial activity against the Gram-positive bacteria Bacillus subtilis (MIC 0.2-1.6 µg mL

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAscomycotaDepsidesMicrobial Sensitivity TestsAustraliaBacillus subtilisMethicillin-Resistant Staphylococcus aureusMolecular StructureSaccharomyces cerevisiaeStaphylococcus aureusAnti-Bacterial AgentsAntifungal AgentsDepsides

Identifiers

PMID38926492
PMCPMC11427298

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.