ArticleNature communications2024
Selection and horizontal gene transfer underlie microdiversity-level heterogeneity in resistance gene fate during wastewater treatment.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Re-Emerging Bacterial Pathogens, Resistance Genes and Promising Bioindicators in Raw and Treated Sewage-Addressing a Known Issue from a Different Angle and Perspective.Microorganisms · 2026Article
- City-scale resistome-mobilome architecture and mobility-associated ARG backbones across a megacity watershed.iScience · 2026Article
- Cobalt and nickel ion synergy promotes gene amplification and stable metal resistance inApplied and environmental microbiology · 2026Article
- Enhanced Antibiotics Sieving by Exfoliated TiSNano-micro letters · 2026Article
- Systematic citywide analysis reveals ecological connectivity of antimicrobial resistance genes across urban water systems.Nature communications · 2026Article
- High-throughput sequencing dataset of raw and treated wastewater from Jeddah, Saudi Arabia.Data in brief · 2026Article
- Genome-Wide DNA Methylation and Restriction-Modification Systems inMicroorganisms · 2026Article
- Citywide metagenomics reveals microbial community and resistome dynamics in urban wastewater.Nature communications · 2026Article
- The mobile resistome in the water-soil-air nexus: horizontal gene transfer and environmental dissemination of antimicrobial resistance genes.FEMS microbiology ecology · 2026Review
- Phylogenetic Analysis of blaEcoHealth · 2026Article
- Bacteriophage survival and ARG dissemination from wastewater treatment plants to the environment.Applied microbiology and biotechnology · 2026Review
- Horizontal and vertical gene transfer shape the plasmid host range in surface-associated microbial systems.iScience · 2026Article
- Genomic Epidemiology of NDM-1 Carbapenemase-ProducingAntibiotics (Basel, Switzerland) · 2026Article
- First Report and Comprehensive Risk Index ofMicroorganisms · 2026Article
- Soil antibiotic resistome in farmland exhibits higher diversity and horizontal transfer potential than adjacent pastureland in agro-pastoral ecotone.Environmental microbiome · 2026Article
- Host-linked virome assembly and turnover predict bacterial community structure in wastewater treatment systems.The ISME journal · 2026Article
- Hidden carriers: multidrug-resistant bacteria in hedgehogs from a wildlife rescue centre.Frontiers in veterinary science · 2026Article
- Editorial: Microbial adaptation and metabolic reprogramming under emerging contaminants stress in engineered water/wastewater treatment ecosystems.Frontiers in microbiology · 2026Article
- Versatile wastewater monitoring of pathogens and antimicrobial resistance enabled by metatranscriptomics and long-read metagenomics.Research square · 2025Article
- Mobilome-mediated transcriptional activation of biosynthetic gene clusters and its impact on strain competitiveness in food fermentation microbiomes.Microbiome · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Activated sludge is the centerpiece of biological wastewater treatment, as it facilitates removal of sewage-associated pollutants, fecal bacteria, and pathogens from wastewater through semi-controlled microbial ecology. It has been hypothesized that horizontal gene transfer facilitates the spread of antibiotic resistance genes within the wastewater treatment plant, in part because of the presence of residual antibiotics in sewage. However, there has been surprisingly little evidence to suggest that sewage-associated antibiotics select for resistance at wastewater treatment plants via horizontal gene transfer or otherwise. We addressed the role of sewage-associated antibiotics in promoting antibiotic resistance using lab-scale sequencing batch reactors fed field-collected wastewater, metagenomic sequencing, and our recently developed bioinformatic tool Kairos. Here, we found confirmatory evidence that fluctuating levels of antibiotics in sewage are associated with horizontal gene transfer of antibiotic resistance genes, microbial ecology, and microdiversity-level differences in resistance gene fate in activated sludge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.