Evidence map›Paper›PMID 38926381›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2024

[Melatonin alleviates autophagy in cortical neurons of neonatal rats with hypoxic- ischemic brain damage via the PI3K/AKT pathway].

Chen-Meng Liu, Xiao-Tian Gao, Hai-Mo Zhang, Hui-Ning Bi, Chen Liang, Jing-Ying Jiang, Pei-Lun Xiao, Xiao-He Yu, Xiao-Li Wang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen-Meng LiuSchool of Medical Imaging, Shandong Second Medical University, Weifang, Shandong 261053, China.
Xiao-Tian GaoSchool of Medical Imaging, Shandong Second Medical University, Weifang, Shandong 261053, China.
Hai-Mo ZhangSchool of Medical Imaging, Shandong Second Medical University, Weifang, Shandong 261053, China.
Hui-Ning BiSchool of Medical Imaging, Shandong Second Medical University, Weifang, Shandong 261053, China.
Chen LiangSchool of Medical Imaging, Shandong Second Medical University, Weifang, Shandong 261053, China.
Jing-Ying Jiang
Pei-Lun Xiao
Xiao-He Yu
Xiao-Li WangSchool of Medical Imaging, Shandong Second Medical University, Weifang, Shandong 261053, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo observe the effects of melatonin on autophagy in cortical neurons of neonatal rats with hypoxic-ischemic brain damage (HIBD) and to explore its mechanisms via the PI3K/AKT signaling pathway, aiming to provide a basis for the clinical application of melatonin.

methodsSeven-day-old Sprague-Dawley neonatal rats were randomly divided into a sham operation group, an HIBD group, and a melatonin group (

resultsTwenty-four hours post-modeling, neurons in the sham operation group displayed normal size and orderly arrangement. In contrast, neurons in the HIBD group showed swelling and disorderly arrangement, while those in the melatonin group had relatively normal morphology and more orderly arrangement. Nissl bodies were normal in the sham operation group but distorted in the HIBD group; however, they remained relatively intact in the melatonin group. The average fluorescence intensity of LC3 and Beclin-1 was higher in the HIBD group compared to the sham operation group, but was reduced in the melatonin group compared to the HIBD group (

conclusionsMelatonin can inhibit excessive autophagy in cortical neurons of neonatal rats with HIBD, thereby alleviating HIBD. This mechanism is associated with the PI3K/AKT pathway.

Indexed as

Animals, NewbornAutophagyCerebral CortexHypoxia-Ischemia, BrainMelatoninNeuronsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRats, Sprague-DawleySignal TransductionAnimalsFemaleMaleRatsMelatoninPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAutophagyCerebral cortexHypoxic-ischemic brain damageNeonatal ratPI3K/AKT pathway

Identifiers

PMID38926381
PMCPMC11562057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.