Evidence map›Paper›PMID 38926377›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2024

[Expression of miR-142 and its relationship with Th17/Treg imbalance in children with autoimmune thyroid disease].

Ping Luo, Yan-Mei Xin, Qu-Lian Guo, Xing Shen

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Ping LuoDepartment of Pediatrics, Affiliated Hospital of Southwest Medical University/Laboratory of Pediatric Hematology Oncology and Birth Defects/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.
Yan-Mei XinDepartment of Pediatrics, Affiliated Hospital of Southwest Medical University/Laboratory of Pediatric Hematology Oncology and Birth Defects/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.
Qu-Lian GuoDepartment of Pediatrics, Affiliated Hospital of Southwest Medical University/Laboratory of Pediatric Hematology Oncology and Birth Defects/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.
Xing ShenDepartment of Pediatrics, Affiliated Hospital of Southwest Medical University/Laboratory of Pediatric Hematology Oncology and Birth Defects/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the expression of microRNA-142 (miR-142) in children with autoimmune thyroid disease (AITD) and its relationship with the imbalance of helper T cell 17 (Th17) and regulatory T cell (Treg).

methodsA total of 89 children hospitalized for AITD from January 2019 to December 2022 were prospectively selected as the study subjects, including 48 children with Graves' disease (GD group) and 41 children with Hashimoto's thyroiditis (HT group). Additionally, 55 healthy children undergoing physical examinations during the same period were selected as the control group. The differences in serum miR-142, antithyroglobulin antibody (TGAb), antithyroperoxidase antibody (TPOAb), Th17/Treg, and interleukin-17 (IL-17) expression were compared among the groups.

resultsThe expression of miR-142, TPOAb, TGAb, Th17, Th17/Treg, and IL-17 in the GD group and HT group was higher than that in the control group, while Treg was lower than that in the control group (

conclusionsmiR-142 is highly expressed in children with AITD, and its expression may be related to the Th17/Treg imbalance in children with GD.

Indexed as

Interleukin-17MicroRNAsTh17 CellsT-Lymphocytes, RegulatoryAdolescentAutoantibodiesChildChild, PreschoolFemaleGraves DiseaseHashimoto DiseaseHumansMaleAutoantibodiesInterleukin-17MicroRNAsMIRN142 microRNA, humanAutoimmune thyroid diseaseChildHelper T cell 17Immune balancemiR-142Regulatory T cell

Identifiers

PMID38926377
PMCPMC11562060

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