ArticleNature communications2024
METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.
Abstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression.Molecular medicine reports · 2026Article
- Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice.Molecular neurodegeneration · 2026Article
- Quercetin Suppresses Uterine Leiomyoma Progression by Modulating METTL3-Mediated MAPK Signaling.International journal of molecular sciences · 2026Article
- The Role of Stress Granules in Cardiovascular Diseases.Reviews in cardiovascular medicine · 2026Review
- DECODE: deep learning-based common deconvolution framework for various omics data.Nature methods · 2026Article
- Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.Research square · 2026Article
- Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.bioRxiv : the preprint server for biology · 2026Article
- High-order chromatin structures mediated by phase separation in cell senescence.Frontiers in molecular biosciences · 2026Review
- Novel MAFG-METTL14-SCD1 axis regulates lipid metabolism mediating choroidal melanoma distant metastasis.Journal of experimental & clinical cancer research : CR · 2025Article
- Partial Reprogramming in Senescent Schwann Cells Enhances Peripheral Nerve Regeneration via Restoration of Stress Granule Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nuclear FGF2 orchestrates phase separation-mediated rDNA chromatin architecture to control BMSCs cell fate.Bone research · 2025Article
- Mechanistic exploration of hexokinase 2 and metabolism in diabetic cardiomyopathy.Molecular medicine reports · 2025Article
- METTL3-mediated mActa biochimica et biophysica Sinica · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Chen WangDepartment of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA.
Hideki TanizawaInstitute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA.
Connor HillGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Aaron HavasSanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.
Qiang ZhangGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Liping LiaoDepartment of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA.
Xue HaoDepartment of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA.ORCID 0000-0003-4138-1447
Xue LeiSanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.
Lu WangPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hao NieDepartment of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA.
Yuan QiDepartment of Bioinformatics & Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.ORCID 0000-0001-9718-7593
Bin TianGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.ORCID 0000-0001-8903-8256
Alessandro GardiniGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.ORCID 0000-0003-0413-2855
Andrew V KossenkovImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Aaron GoldmanMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.ORCID 0000-0001-7605-9592
Shelley L BergerPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5398-4400
Ken-Ichi NomaInstitute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA.ORCID 0000-0002-5187-6788
Peter D AdamsSanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.ORCID 0000-0002-0684-1770
Rugang ZhangDepartment of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA. rzhang11@mdanderson.org.ORCID 0000-0002-7255-2360
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MTumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MSTRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI MARMORSTEIN, RONEN · 2008 to 2022
$28.3MNational Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7MRole of BRCA1 Pathway in Regulating Oncogene-Induced SenescenceR01CA160331 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2012 to 2021
$4.0MBiomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2MSignaling basis of senescence-associated secretory phenotype and its implications in epithelial ovarian cancerR01CA276569 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Rugang Zhang · 2023 to 2026
$2.1MRegulation of gene expression by alternative polyadenylationR35GM153277 · NIGMS · WISTAR INSTITUTE · PI BIN TIAN · 2024 to 2026
$2.0MIntegrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6MRegulation and Functions of 3'UTRs in Cellular StressR01GM129069 · NIGMS · WISTAR INSTITUTE · PI TIAN, BIN · 2018 to 2021
$1.5MMechanisms of enhancer regulation in aging and age-related diseasesR00AG065500 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WANG, LU · 2023 to 2025
$742kNCI NIH HHS P30 CA010815NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA160331NCI NIH HHS R01 CA276569NIA NIH HHS P01 AG031862NIA NIH HHS R00 AG065500NIDDK NIH HHS U2C DK119886NIGMS NIH HHS R01 GM129069NIGMS NIH HHS R35 GM153277NIH HHS OT2 OD030544U.S. Department of Health & Human Services | National Institutes of Health (NIH) P01AG031862U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA160331U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA276569
Abstract
METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m
Indexed as
Cellular SenescenceChromatinMethyltransferasesStress GranulesAdenosineHEK293 CellsHexokinaseHumansMetabolic ReprogrammingPhase SeparationRNA, MessengerAdenosineChromatinHexokinaseMethyltransferasesMETTL3 protein, humanRNA, Messenger
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.