Evidence map›Paper›PMID 38926339›Full record

ReviewNature communications2024

Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists.

Ashty S Karim, Dylan M Brown, Chloé M Archuleta, Sharisse Grannan, Ludmilla Aristilde, Yogesh Goyal, Josh N Leonard, Niall M Mangan, Arthur Prindle, Gabriel J Rocklin and 7 more

Abstract readReview
In one paragraph

Review in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ashty S KarimCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA. ashty.karim@northwestern.edu.ORCID 0000-0002-5789-7715
Dylan M BrownCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0001-8153-7683
Chloé M ArchuletaCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.
Sharisse GrannanCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.
Ludmilla AristildeCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-8566-1486
Yogesh GoyalCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0003-3502-6465
Josh N LeonardCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0003-4359-6126
Niall M ManganCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-3491-8341
Arthur PrindleCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.
Gabriel J RocklinCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.
Keith J TyoCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-2342-0687
Laurie ZolothCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.
Michael C JewettCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.
Susanna CalkinsCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.ORCID 0009-0001-3653-0236
Neha P KamatCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0001-9362-6106
Danielle Tullman-ErcekCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0001-6734-480X
Julius B LucksCenter for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA. jblucks@northwestern.edu.ORCID 0000-0002-0619-6505

Funding

National Science Foundation (NSF) 2021900
6 · The paper itself

Abstract

Synthetic biology allows us to reuse, repurpose, and reconfigure biological systems to address society's most pressing challenges. Developing biotechnologies in this way requires integrating concepts across disciplines, posing challenges to educating students with diverse expertise. We created a framework for synthetic biology training that deconstructs biotechnologies across scales-molecular, circuit/network, cell/cell-free systems, biological communities, and societal-giving students a holistic toolkit to integrate cross-disciplinary concepts towards responsible innovation of successful biotechnologies. We present this framework, lessons learned, and inclusive teaching materials to allow its adaption to train the next generation of synthetic biologists.

Indexed as

Synthetic BiologyBiotechnologyHumansStudents

Identifiers

PMID38926339
PMCPMC11208543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.