Evidence map›Paper›PMID 38926330›Full record

ArticleCurrent medical science2024

Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint: A Retrospective Analysis.

Su-Guo Wang, Yong-Gang Wang, Guo-Wei Qian, Li-Na Tang, Xin Zhou, Dong-Dong Cheng, Chen-Liang Zhou, Qing-Cheng Yang, Zan Shen, Gao-Zhong Huang and 1 more

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Article in Current medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Dyslipidaemias in cancer patients.European heart journal · 2026
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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Su-Guo Wang *Department of General Medicine, Shenzhen Third People's Hospital, Shenzhen, 518112, China.
Yong-Gang Wang *Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Guo-Wei QianDepartment of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Li-Na TangDepartment of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Xin ZhouCancer Research Institute of Jilin University, The First Hospital of Jilin University, Changchun, 130021, China.
Dong-Dong ChengDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Chen-Liang ZhouDepartment of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Qing-Cheng YangDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Zan ShenDepartment of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Gao-Zhong HuangDepartment of VIP Clinic, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. huanggaozhong@126.com.
Hong-Tao LiDepartment of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. Lhtmed@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant chemotherapy.

methodsAfter retrospectively screening the data of 742 patients between January 2007 and July 2020, 50 patients aged 13 to 39 years with Enneking stage II disease were included in the study. Serum lipid levels, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), lipoprotein-α [Lp(a)], and apolipoprotein A1, B, and E (ApoA1, ApoB, and ApoE), and clinicopathological characteristics were collected before and after neoadjuvant chemotherapy.

resultsThe mean levels of TC, TG, and ApoB were significantly increased following neoadjuvant chemotherapy (16%, 38%, and 20%, respectively, vs. pretreatment values; P<0.01). The mean levels of LDL-C and ApoE were also 19% and 16% higher, respectively (P<0.05). No correlation was found between the pretreatment lipid profile and the histologic response to chemotherapy. An increase in Lp(a) was strongly correlated with the Ki-67 index (R=0.31, P=0.023). Moreover, a trend toward longer disease-free survival (DFS) was observed in patients with decreased TG and increased LDL-C following chemotherapy, although this difference was not statistically significant (P=0.23 and P=0.24, respectively).

conclusionSignificant elevations in serum lipids were observed after neoadjuvant chemotherapy in patients with localized osteosarcoma. There was no prognostic significance of pretreatment serum lipid levels on histologic response to neoadjuvant chemotherapy. The scale of increase in serum Lp(a) might have a potential prognostic role in osteosarcoma. Patients with increased LDL-C or reduced TG after chemotherapy seem to exhibit a trend toward favorable DFS.

Indexed as

Knee JointLipidsLipoproteinsNeoadjuvant TherapyOsteosarcomaAdolescentAdultBone NeoplasmsFemaleHumansMaleRetrospective StudiesYoung AdultLipidsLipoproteinsneoadjuvant chemotherapyosteosarcomaserum lipids

Identifiers

PMID38926330

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