Evidence map›Paper›PMID 38926279›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Expression of Multispecific Antibodies.

Megane Peltret, Angelique Schmid, Lionel Duarte, Romain Mette, Roberto Giovannini, Martin Bertschinger

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Megane PeltretIchnos Sciences SA, La Chaux-de-Fonds, Switzerland.
Angelique SchmidIchnos Sciences SA, La Chaux-de-Fonds, Switzerland.
Lionel DuarteIchnos Sciences SA, La Chaux-de-Fonds, Switzerland.
Romain MetteIchnos Sciences SA, La Chaux-de-Fonds, Switzerland.
Roberto GiovanniniIchnos Sciences SA, La Chaux-de-Fonds, Switzerland.
Martin BertschingerIchnos Sciences SA, La Chaux-de-Fonds, Switzerland. Martin.Bertschinger@Ichnossciences.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bi- and multispecific antibody formats allow the development of new therapeutic strategies to address previously unmet medical needs. However, due to the increased complexity (e.g., the interface design and the presence of multiple binders), such molecules are generally more challenging to express and purify compared to standard monoclonal antibodies (mAbs). We describe here an optimized methodology to express and purify basic bispecific antibodies using the BEAT

Indexed as

Antibodies, BispecificAnimalsAntibodies, MonoclonalGene ExpressionHumansProtein EngineeringAntibodies, BispecificAntibodies, MonoclonalBEATBioreactor processBispecific antibodyDownstream processingExpression vectorMultispecific antibodyStable expression

Identifiers

PMID38926279

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.