Evidence map›Paper›PMID 38926174›Full record

ArticleAbdominal radiology (New York)2024

Magnetic resonance imaging T1 mapping of the liver, pancreas and spleen in children.

Pradipta Debnath, Jean A Tkach, Michelle Saad, David S Vitale, Maisam Abu-El-Haija, Andrew T Trout

Abstract read
In one paragraph

Article in Abdominal radiology (New York), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pradipta DebnathDepartment of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Kasota Building MLC 5031, Cincinnati, OH, 45229, USA.
Jean A TkachDepartment of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Kasota Building MLC 5031, Cincinnati, OH, 45229, USA.
Michelle SaadDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
David S VitaleDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Maisam Abu-El-HaijaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Andrew T TroutDepartment of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Kasota Building MLC 5031, Cincinnati, OH, 45229, USA. andrew.trout@cchmc.org.ORCID 0000-0003-1431-4054

Funding

Multi-parametric quantitative MRI for assessment of pancreas health in childrenR01DK132346 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI TROUT, ANDREW TIMOTHY · 2022 to 2024
$2.0M
NIDDK NIH HHS 1R01DK132346-01NIDDK NIH HHS R01 DK132346
6 · The paper itself

Abstract

purposeTo characterize T1 relaxation times of the pancreas, liver, and spleen in children with and without abdominal pathology.

methodsThis retrospective study included pediatric patients (< 18-years-old). T1 mapping was performed with a Modified Look-Locker Inversion Recovery sequence. Patients were grouped based on review of imaging reports and electronic medical records. The Kruskal-Wallis test with Dunn's multiple comparison was used to compare groups.

results220 participants were included (mean age: 11.4 ± 4.2 years (1.5 T); 10.9 ± 4.5 years (3 T)). Pancreas T1 (msec) was significantly different between subgroups at 1.5 T (p < 0.0001). Significant pairwise differences included: normal (median: 583; IQR: 561-654) vs. acute pancreatitis (731; 632-945; p = 0.0024), normal vs. chronic pancreatitis (700; 643-863; p = 0.0013), and normal vs. acute + chronic pancreatitis (1020; 897-1099; p < 0.0001). Pancreas T1 was also significantly different between subgroups at 3 T (p < 0.0001). Significant pairwise differences included: normal (779; 753-851) vs. acute pancreatitis (1087; 910-1259; p = 0.0012), and normal vs. acute + chronic pancreatitis (1226; 1025-1367; p < 0.0001). Liver T1 was significantly different between subgroups only at 3 T (p = 0.0011) with pairwise differences between normal (818, 788-819) vs. steatotic (959; 848-997; p = 0.0017) and normal vs. other liver disease (882; 831-904; p = 0.0455). Liver T1 was weakly correlated with liver fat fraction at 1.5 T (r = 0.39; 0.24-0.52; p < 0.0001) and moderately correlated at 3 T (r = 0.64; 0.49-0.76; p < 0.0001). There were no significant differences in splenic T1 relaxation times between subgroups.

conclusionPancreas T1 relaxation times are higher at 1.5 T and 3 T in children with pancreatitis and liver T1 relaxation times are higher in children with steatotic and non-steatotic chronic liver disease at 3 T.

Indexed as

LiverMagnetic Resonance ImagingPancreasSpleenAdolescentChildChild, PreschoolFemaleHumansMalePancreatitisRetrospective StudiesMRIPancreatitisPediatricsSteatosisT1 mapping

Identifiers

PMID38926174
PMCPMC11519179

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.