Evidence map›Paper›PMID 38926162›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Synthesis, preclinical evaluation and pilot clinical translation of [

Rongxi Wang, Zhidong Bai, Wentao Zhong, Chenzhen Li, Jiarou Wang, Jialin Xiang, Junfeng Du, Bing Jia, Zhaohui Zhu

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05937919 (CLDN18.2 Targeted 68Ga-PMD22 PET Imaging in Patients With Gastrointestinal Tumours), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05937919 early_phase1unknown statusnot on this map

CLDN18.2 Targeted 68Ga-PMD22 PET Imaging in Patients With Gastrointestinal Tumours

TypeinterventionalSponsorPeking Union Medical College HospitalRan2023 to 2023Enrolled10ConditionsGastrointestinal CancerArmsIntravenous injection of 68Ga-PMD22
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Nanobodies targeting SARS-CoV-2 variants.Acta pharmaceutica Sinica. B · 2026
    Review
  2. Article
  3. Review
  4. Article
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rongxi Wang *Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China.
Zhidong Bai *Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Wentao Zhong *Medical Department of General Surgery, The 1st Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Chenzhen LiDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Jiarou WangDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China.
Jialin XiangDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China.
Junfeng DuMedical Department of General Surgery, The 1st Medical Center, Chinese PLA General Hospital, Beijing, 100853, China. dujf66@126.com.
Bing JiaDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191, China. jiabing@bjmu.edu.cn.
Zhaohui ZhuDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China. 13611093752@163.com.

Funding

Chinese Academy of Medical Science Innovation Fund for Medical Sciences 2021-I2M-1-016Chinese Academy of Medical Science Innovation Fund for Medical Sciences 2022-I2M-2-002Chinese Academy of Medical Science Innovation Fund for Medical Sciences 2022-I2M-C&T-A-008Fundamental Research Funds for the Central Universities 3332023124National High Level Hospital Clinical Research Funding 2022-PUMCH-C-004National High Level Hospital Clinical Research Funding 2022-PUMCH-D-002National Natural Science Foundation of China 81870393National Natural Science Foundation of China 81871416National Natural Science Foundation of China 82172006National Natural Science Foundation of China 82272046
6 · The paper itself

Abstract

purposeClaudin18.2 (CLDN18.2) is a novel target for diagnosis and therapy of gastrointestinal cancer. This study aimed to evaluate the safety and feasibility of a novel CLDN18.2-targeted nanobody, PMD22, labeled with gallium-68 ([

methods[

resultsCell binding assay showed that [

conclusionA novel [ CLINICAL

trial registrationThis study was registered on the ClinicalTrials.gov (NCT05937919).

Indexed as

ClaudinsGallium RadioisotopesGastrointestinal NeoplasmsPositron Emission Tomography Computed TomographyAgedAnimalsCell Line, TumorFemaleHumansMaleMiceMiddle AgedPilot ProjectsSingle-Domain AntibodiesTissue DistributionClaudinsCLDN18 protein, humanGallium-68Gallium RadioisotopesSingle-Domain Antibodies[68Ga]Ga-PMD22Claudin 18.2Gastrointestinal cancerNanobodyPET/CT

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.