Evidence map›Paper›PMID 38926079›Full record

ArticleGut2024

Gut microbiota signatures of vulnerability to food addiction in mice and humans.

Solveiga Samulėnaitė, Alejandra García-Blanco, Jordi Mayneris-Perxachs, Laura Domingo-Rodríguez, Judit Cabana-Domínguez, Noèlia Fernàndez-Castillo, Edurne Gago-García, Laura Pineda-Cirera, Aurelijus Burokas, Jose Espinosa-Carrasco and 9 more

Abstract read
In one paragraph

Article in Gut, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
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  9. Supplementation with abioRxiv : the preprint server for biology · 2025
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  18. Intermittent supplementation withFrontiers in aging neuroscience · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Solveiga Samulėnaitė *Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain.ORCID 0000-0001-7226-672X
Alejandra García-Blanco *Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain.
Jordi Mayneris-Perxachs *Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain.ORCID 0000-0003-3788-3815
Laura Domingo-RodríguezLaboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain.
Judit Cabana-DomínguezDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0002-4732-7284
Noèlia Fernàndez-CastilloDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0001-9948-0312
Edurne Gago-GarcíaDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.ORCID 0009-0002-6369-9982
Laura Pineda-CireraDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Aurelijus BurokasDepartment of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID 0000-0002-0364-3496
Jose Espinosa-CarrascoCentre for Genomic Regulation (CRG), Barcelona, Spain.
Silvia ArboleyaAPC Microbiome Institute, University College Cork, Cork, Ireland.
Jessica LatorreNutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain.
Catherine StantonAPC Microbiome Institute, University College Cork, Cork, Ireland.ORCID 0000-0002-6724-7011
Koji HosomiLaboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, Japan. (NIBIOHN), Ibaraki, Osaka, Japan.
Jun KunisawaLaboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, Japan. (NIBIOHN), Ibaraki, Osaka, Japan.ORCID 0000-0003-4901-1125
Bru CormandDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0001-5318-4382
Jose Manuel Fernández-RealNutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain rafael.maldonado@upf.edu jmfreal@idibgi.org elena.martin@upf.edu.ORCID 0000-0002-7442-9323
Rafael MaldonadoLaboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain rafael.maldonado@upf.edu jmfreal@idibgi.org elena.martin@upf.edu.ORCID 0000-0002-4359-8773
Elena Martín-GarcíaLaboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain rafael.maldonado@upf.edu jmfreal@idibgi.org elena.martin@upf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFood addiction is a multifactorial disorder characterised by a loss of control over food intake that may promote obesity and alter gut microbiota composition. We have investigated the potential involvement of the gut microbiota in the mechanisms underlying food addiction.

designWe used the Yale Food Addiction Scale (YFAS) 2.0 criteria to classify extreme food addiction in mouse and human subpopulations to identify gut microbiota signatures associated with vulnerability to this disorder.

resultsBoth animal and human cohorts showed important similarities in the gut microbiota signatures linked to food addiction. The signatures suggested possible non-beneficial effects of bacteria belonging to the Proteobacteria phylum and potential protective effects of Actinobacteria against the development of food addiction in both cohorts of humans and mice. A decreased relative abundance of the species

conclusionBy understanding the crosstalk between this behavioural alteration and gut microbiota, these findings constitute a step forward to future treatments for food addiction and related eating disorders.

Indexed as

Food AddictionGastrointestinal MicrobiomeAdultAnimalsFecesFemaleHumansMaleMiceMice, Inbred C57BLNEUROPHARMACOLOGYNUTRITIONOBESITYPSYCHOLOGY

Identifiers

PMID38926079
PMCPMC11503113

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.