Evidence map›Paper›PMID 38925660›Full record

ArticleAging2024

Prescription glucocorticoid medication and iridocyclitis are associated with an increased risk of senile cataract occurrence: a Mendelian randomization study.

Rui Wen, Yu-Jia Xi, Ran Zhang, Si-Jia Hou, Jin-Yu Shi, Jin-Yi Chen, He-Yi Zhang, Jun Qiao, Yi-Qian Feng, Sheng-Xiao Zhang

Abstract read
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rui WenDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Yu-Jia XiShanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, China.
Ran ZhangShanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, China.
Si-Jia HouShanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, China.
Jin-Yu ShiShanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, China.
Jin-Yi ChenShanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, China.
He-Yi ZhangShanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, China.
Jun QiaoDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Yi-Qian FengShanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, China.
Sheng-Xiao ZhangDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iridocyclitis and the use of glucocorticoid medication have been widely studied as susceptibility factors for cataracts. However, the causal relationship between them remains unclear. This study aimed to investigate the causal relationship between the development of iridocyclitis and the genetic liability of glucocorticoid medication use on the risk of senile cataracts occurrence by performing Two-sample Mendelian randomization (MR) analyses. Instrumental variables (IVs) significantly associated with exposure factors (P < 5 × 10

Indexed as

CataractGlucocorticoidsIridocyclitisMendelian Randomization AnalysisAgedGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansRisk FactorsGlucocorticoidsiridocyclitisMendelian randomizationprescription glucocorticoid medication usesenile cataractssingle nucleotide polymorphisms

Identifiers

PMID38925660
PMCPMC11236313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.