Trial reportJournal of affective disorders2024
Relationship between Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) total scores in older adults with major depressive disorder: An analysis of the OPTIMUM clinical trial.
Trial report in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Efficacy and safety of Toludesvenlafaxine extended-release tablets in the treatment of treatment-resistant depression.BMC psychiatry · 2025Trial
- Article
- Digital phenotyping with large language models to detect depressive state changes in patients.NPJ digital medicine · 2026Article
- The Digital Mental Health Study assessed feasibility of large-scale digital sensing for depression and anxiety.npj digital public health · 2026Article
- Real-world evaluation of change in depressive symptoms among patients with treatment-resistant depression treated with esketamine.BMC psychiatry · 2025Article
- Urban riverbank green spaces as therapeutic environments: Examining the psychosocial benefits of square dance in aging populations in China.SSM - population health · 2025Article
- Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Everyday functioning in treatment-resistant late-life depression: The mediating role of cognition.Journal of the International Neuropsychological Society : JINS · 2025Article
- Association between dietary self-care adherence and depression among adults living with type 2 diabetes mellitus in Ghana: a cross-sectional study.Journal of health, population, and nutrition · 2025Article
- Validation of the Vietnamese version of the Montgomery-Asberg depression rating scale (MADRS) in rheumatoid arthritis patients.PLOS mental health · 2025Article
- The challenges of integrating diverse data sources: A case study in major depression.Health services & outcomes research methodology · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundThe Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) are commonly used scales to measure depression severity in older adults.
methodsWe utilized data from the Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM) clinical trial to produce conversion tables relating PHQ-9 and MADRS total scores. We split the sample into training (N = 555) and validation samples (N = 187). Equipercentile linking was performed on the training sample to produce conversion tables for PHQ-9 and MADRS. We compared the original and estimated scores in the validation sample with Bland-Altman analysis. We compared the depression severity level using the original and estimated scores with Chi-square tests.
resultsThe Bland-Altman analysis confirmed that differences between the original and estimated scores for at least 95 % of the sample fit within 1.96 standard deviations of the mean difference. Chi-square tests showed a significant difference in the proportion of participants at each depression severity category determined using the original and estimated scores. LIMITATIONS: The conversion tables should be used with caution when comparing depression severity at the individual level.
conclusionsOur conversion tables relating PHQ-9 and MADRS scores can be used to compare treatment outcomes using aggregate data in studies that only used one of these scales.
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