Evidence map›Paper›PMID 38925115›Full record

ArticleMolecular cell2024

Structure of the Hir histone chaperone complex.

Hee Jong Kim, Mary R Szurgot, Trevor van Eeuwen, M Daniel Ricketts, Pratik Basnet, Athena L Zhang, Austin Vogt, Samah Sharmin, Craig D Kaplan, Benjamin A Garcia and 2 more

Abstract read
In one paragraph

Article in Molecular cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Mechanism of ASF1 engagement by CDAN1.Nature communications · 2025
    Article
  6. Article
  7. Mechanism of ASF1 Inhibition by CDAN1.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hee Jong KimDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mary R SzurgotDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Trevor van EeuwenDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
M Daniel RickettsDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Pratik BasnetDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Athena L ZhangBiochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Austin VogtDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Samah SharminDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Craig D KaplanDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Benjamin A GarciaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ronen MarmorsteinDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: marmor@upenn.edu.
Kenji MurakamiDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: kenjim@pennmedicine.upenn.edu.

Funding

STRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI BERGER, SHELLEY L · 2008 to 2022
$28.3M
Shared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2015 to 2024
$17.6M
Viral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4M
Functional and structural studies of the transition from transcription initiation to elongationR01GM123233 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MURAKAMI, KENJI · 2017 to 2025
$3.6M
Mechanisms of RNA Polymerase II transcriptionR35GM144116 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Craig Kaplan · 2022 to 2026
$3.4M
Quantitative mass spectrometry for comprehending epigenetic mechanisms in a new underlying neurological developmental disorderR01HD106051 · NICHD · WASHINGTON UNIVERSITY · PI Benjamin A Garcia · 2022 to 2026
$2.6M
Reconstitution and structural dissection of transcription-coupled histone H3.3 depositionF31AG069390 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KIM, HEE JONG · 2020 to 2022
$126k
Role of Multimerization in H3.3/H4 deposition by the HIRA complexF31AG067692 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SZURGOT, MARY · 2021 to 2023
$110k
NCI NIH HHS P01 CA196539NIAID NIH HHS R01 AI118891NIA NIH HHS F31 AG067692NIA NIH HHS F31 AG069390NIA NIH HHS P01 AG031862NICHD NIH HHS R01 HD106051NIGMS NIH HHS R01 GM123233NIGMS NIH HHS R35 GM144116
6 · The paper itself

Abstract

The evolutionarily conserved HIRA/Hir histone chaperone complex and ASF1a/Asf1 co-chaperone cooperate to deposit histone (H3/H4)

Indexed as

Cell Cycle ProteinsCryoelectron MicroscopyHistone ChaperonesHistonesProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsBinding SitesModels, MolecularMolecular ChaperonesProtein Interaction Domains and MotifsProtein MultimerizationTranscription FactorsASF1 protein, S cerevisiaeCell Cycle ProteinsHistone ChaperonesHistonesMolecular ChaperonesSaccharomyces cerevisiae ProteinsTranscription FactorsAsf1chromatincrosslinking mass spectrometrycryo-electron microscopyH3/H4HirHIRAhistone chaperonenucleosometranscription

Identifiers

PMID38925115
PMCPMC11338637

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.