ArticleMolecular cell2024
pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism.
Article in Molecular cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Ribosome remodeling drives translation adaptation during viral infection and cellular stress.Molecular cell · 2026Article
- Review
- Engineering of genetically encoded programmable calcium channel inhibitory binders.Nature communications · 2026Article
- ARIES domains: functional signaling units of type I interferon responses.The FEBS journal · 2025Review
- Ribosome remodeling drives translation adaptation during viral infection and cellular stress.bioRxiv : the preprint server for biology · 2025Article
- STING-induced noncanonical autophagy regulates endolysosomal homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NFκB signaling.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
12 authors.
Funding
Abstract
Signal transduction proteins containing a pLxIS motif induce interferon (IFN) responses central to antiviral immunity. Apart from their established roles in activating the IFN regulator factor (IRF) transcription factors, the existence of additional pathways and functions associated with the pLxIS motif is unknown. Using a synthetic biology-based platform, we identified two orphan pLxIS-containing proteins that stimulate IFN responses independent of all known pattern-recognition receptor pathways. We further uncovered a diversity of pLxIS signaling mechanisms, where the pLxIS motif represents one component of a multi-motif signaling entity, which has variable functions in activating IRF3, the TRAF6 ubiquitin ligase, IκB kinases, mitogen-activated protein kinases, and metabolic activities. The most diverse pLxIS signaling mechanisms were associated with the highest antiviral activities in human cells. The flexibility of domains that regulate IFN signaling may explain their prevalence in nature.
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