Evidence map›Paper›PMID 38924971›Full record

ArticleGeneral hospital psychiatry

Co-occurring psychiatric disorders in young people with eating disorders: An multi-state and real-time analysis of real-world administrative data.

Binx Yezhe Lin, Angela Liu, Hui Xie, Sarah Eddington, Dominic Moog, Kevin Y Xu

Abstract read
In one paragraph

Article in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Binx Yezhe LinDepartment of Psychosomatic Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 145 Rushan Rd, Shanghai 200120, China; Department of Psychiatry and Behavioral Medicine, Carilion Clinic- Virginia Tech Carilion School of Medicine, 2017 S Jefferson St 2nd Floor, Roanoke 24014, VA, USA.
Angela LiuNorthwell Health at Zucker Hillside Hospital, 75-59 263rd St, Glen Oaks 11004, NY, USA.
Hui XieZilber School of Public Health, University of Wisconsin-Milwaukee, 1240 N. 10th St., Milwaukee 53205, WI, USA.
Sarah EddingtonDepartment of Psychiatry, Washington University School of Medicine, 4940 Children's Place, Saint Louis, MO 63110, USA.
Dominic MoogWashington University School of Medicine, 660 S Euclid Ave, St. Louis 63110, MO, USA.
Kevin Y XuHealth & Behavior Research Center, Division of Addiction Science, Prevention & Treatment, Department of Psychiatry, Washington University School of Medicine, 4940 Children's Place, Saint Louis, MO 63110, USA; Center for the Study of Race, Ethnicity & Equity and Institute for Public Health, Washington University School of Medicine, 660 S Euclid Ave, St. Louis 63110, MO, USA. Electronic address: xukeviny@wustl.edu.

Funding

Washington University Career Development Program in Drug Abuse and AddictionK12DA041449 · NIDA · WASHINGTON UNIVERSITY · PI Laura J. Bierut, Patricia A Cavazos-Rehg · 2017 to 2026
$4.2M
NIDA NIH HHS K12 DA041449
6 · The paper itself

Abstract

objectiveWe aimed to use real-world data to characterize the burden of psychiatric comorbidities in young people with eating disorders (EDs) relative to peers without EDs.

methodThis retrospective cohort study used a large federated multi-national network of real-time electronic health records. Our cohort consisted of 124,575 people (14,524 people receiving their index, first-ever, ED diagnosis, compared to 110,051 peers without EDs initiating antidepressants). After 1:1 propensity score matching of the two cohorts by pre-existing demographic and clinical characteristics, we used multivariable logistic regression to compute the adjusted odds ratio (aOR) of psychiatric diagnoses arising in the year following the index event (either first ED diagnosis or first antidepressant script).

resultsOver 50% of people with EDs had prior psychiatric diagnoses in the year preceding the index EDs diagnosis, with mood disorders, generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), specific phobia (SP), attention-deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD) being the most common. Adjusted analyses showed higher odds for mood disorders (aOR = 1.20 [95% CI = 1.14-1.26]), GAD (aOR = 1.28 [1.21-1.35]), PTSD (aOR = 1.29 [1.18-1.40]), and SP (aOR = 1.45 [1.31-1.60]) in the EDs cohort compared to antidepressant-initiating peers without EDs, although rates of ADHD and ASD were similar in both cohorts.

conclusionThis large-scale real-time analysis of administrative data illustrates a high burden of co-occurring psychiatric disorders in people with EDs.

Indexed as

ComorbidityFeeding and Eating DisordersAdolescentAdultAnxiety DisordersAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderChildElectronic Health RecordsFemaleHumansMaleMental DisordersMood DisordersRetrospective StudiesStress Disorders, Post-TraumaticBig dataCo-occurring disordersEating disordersReal world data

Identifiers

PMID38924971
PMCPMC11390323

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.