ArticleCNS neuroscience & therapeutics2024
Association between modified frailty index and postoperative delirium in patients after cardiac surgery: A cohort study of 2080 older adults.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of frailty on postoperative delirium in ICU patients aged 65 and older: a systematic review.BMJ open · 2026Pooled it
- Efficacy of Repetitive Transcranial Magnetic Stimulation on Postoperative Delirium in Elderly Patients Undergoing Non-Cardiac Major Surgery: A Randomized Controlled Trial.Brain and behavior · 2026Trial
- Serum C1q as a Novel Predictive Biomarker for Postoperative Delirium After Acute Type A Aortic Dissection.Immunity, inflammation and disease · 2026Article
- Associations of postoperative delirium with perioperative frailty worsening and their combined effect on 1-year mortality in older surgical patients: a prospective cohort study.European geriatric medicine · 2026Article
- Impact of oral frailty on postoperative delirium in older patients undergoing off-pump coronary artery bypass grafting: a prospective observational study.BMC anesthesiology · 2026Observational
- Article
- Observational
- Interpretable machine learning model for predicting delirium in patients with sepsis: a study based on the MIMIC data.BMC infectious diseases · 2025Article
- Frailty as an independent risk factor for sepsis-associated delirium: a cohort study of 11,740 older adult ICU patients.Aging clinical and experimental research · 2025Article
- Associations of Frailty Status and Sleep Quality With Incident Delirium: A Prospective Study in the UK Biobank.CNS neuroscience & therapeutics · 2025Article
- Older Patients' Postoperative Neurocognitive Recovery: A Narrative Review.Clinical interventions in aging · 2025Review
- Bridging nutrition and neurology: malnutrition's role in perioperative neurocognitive disorders.Frontiers in nutrition · 2025Review
- Development and internal verification of nomogram for forecasting delirium in the elderly admitted to intensive care units: an analysis of MIMIC-IV database.Frontiers in neurology · 2025Article
- Association between modified frailty index and postoperative delirium in patients after cardiac surgery: A cohort study of 2080 older adults.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
aimTo evaluate the association between frailty and postoperative delirium (POD) in elderly cardiac surgery patients.
methodsA retrospective study was conducted of older patients admitted to the intensive care unit after cardiac surgery at a tertiary academic medical center in Boston from 2008 to 2019. Frailty was measured using the Modified Frailty Index (MFI), which categorized patients into frail (MFI ≥3) and non-frail (MFI = 0-2) groups. Delirium was identified using the confusion assessment method for the intensive care unit and nursing notes. Logistic regression models were used to examine the association between frailty and POD, and odds ratios (OR) with 95% confidence intervals (CI) were calculated.
resultsOf the 2080 patients included (median age approximately 74 years, 30.9% female), 614 were frail and 1466 were non-frail. The incidence of delirium was significantly higher in the frail group (29.2% vs. 16.4%, p < 0.05). After adjustment for age, sex, race, marital status, Acute Physiology Score III (APSIII), sequential organ failure assessment (SOFA), albumin, creatinine, hemoglobin, white blood cell count, type of surgery, alcohol use, smoking, cerebrovascular disease, use of benzodiazepines, and mechanical ventilation, multivariate logistic regression indicated a significantly increased risk of delirium in frail patients (adjusted OR: 1.61, 95% CI: 1.23-2.10, p < 0.001, E-value: 1.85).
conclusionsFrailty is an independent risk factor for POD in older patients after cardiac surgery. Further research should focus on frailty assessment and tailored interventions to improve outcomes.
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