Evidence map›Paper›PMID 38924661›Full record

ArticleAdvanced healthcare materials2024

Surface Engineering for Endothelium-Mimicking Functions to Combat Infection and Thrombosis in Extracorporeal Life Support Technologies.

Morgan Ashcraft, Mark Garren, Orsolya Lautner-Csorba, Vicente Pinon, Yi Wu, Dagney Crowley, Joseph Hill, Yeniselis Morales, Robert Bartlett, Elizabeth J Brisbois and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Morgan AshcraftDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia, 30602, USA.
Mark GarrenSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia, 30602, USA.
Orsolya Lautner-CsorbaDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA.
Vicente PinonDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia, 30602, USA.
Yi WuSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia, 30602, USA.
Dagney CrowleySchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia, 30602, USA.
Joseph HillDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA.
Yeniselis MoralesDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA.
Robert BartlettDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA.
Elizabeth J BrisboisSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia, 30602, USA.
Hitesh HandaDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia, 30602, USA.ORCID 0000-0002-9369-7374

Funding

Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applicationsR01HL134899 · NHLBI · UNIVERSITY OF GEORGIA · PI HANDA, HITESH · 2017 to 2025
$3.0M
Bioinspired antifouling and thromboresistant polymers for blood-contacting interfacesR01HL151473 · NHLBI · UNIVERSITY OF GEORGIA · PI BRISBOIS, ELIZABETH JOY · 2020 to 2023
$1.4M
National Science Foundation 1842396NHLBI NIH HHS R01 HL134899NHLBI NIH HHS R01 HL151473NIH HHS R01HL134899NIH HHS R01HL151473
6 · The paper itself

Abstract

Blood-contacting medical devices routinely fail from the cascading effects of biofouling toward infection and thrombosis. Nitric oxide (NO) is an integral part of endothelial homeostasis, maintaining platelet quiescence and facilitating oxidative/nitrosative stress against pathogens. Recently, it is shown that the surface evolution of NO can mediate cell-surface interactions. However, this technique alone cannot prevent the biofouling inherent in device failure with dynamic blood-contacting applications. This work proposes an endothelium-mimicking surface design pairing controlled NO release with an inherently antifouling polyethylene glycol interface (NO+PEG). This simple, robust, and scalable platform develops surface-localized NO availability with surface hydration, leading to a significant reduction in protein adsorption as well as bacteria/platelet adhesion. Further in vivo thrombogenicity studies show a decrease in thrombus formation on NO+PEG interfaces, with preservation of circulating platelet and white blood cell counts, maintenance of activated clotting time, and reduced coagulation cascade activation. It is anticipated that this bio-inspired surface design will enable a facile alternative to existing surface technologies to address clinical manifestations of infection and thrombosis in dynamic blood-contacting environments.

Indexed as

Nitric OxidePolyethylene GlycolsThrombosisAnimalsBacterial AdhesionBiofoulingBlood PlateletsEndotheliumHumansPlatelet AdhesivenessSurface PropertiesNitric OxidePolyethylene Glycolsantifoulingantimicrobialhemocompatiblenitric oxidepolyethylene glycol

Identifiers

PMID38924661
PMCPMC11468007

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.