Evidence map›Paper›PMID 38924581›Full record

ArticleElectrophoresis2024

Development of capillary electrophoresis methods for the detection of microbial metabolites on potential future spaceflight missions.

Emily A Kurfman, Maria F Mora, Peter A Willis, Susan M Lunte

Abstract read
In one paragraph

Article in Electrophoresis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emily A KurfmanDepartment of Chemistry, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0002-7081-2157
Maria F MoraJet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA.ORCID 0000-0002-6341-8485
Peter A WillisJet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA.
Susan M LunteDepartment of Chemistry, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0002-1195-0314

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
Synthetic Chemical Biology CoreP30GM145499 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Erik A Lundquist · 2022 to 2026
$6.9M
TRAINING GRANT IN DYNAMIC ASPECTS OF CHEMICAL BIOLOGYT32GM008545 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LAMB, AUDREY L · 1994 to 2019
$4.9M
NASA 80NM0018D0004NASA 80NSSC20K1208National Institutes of General Medical Sciences P20GM103638National Institutes of General Medical Sciences P30GM145499National Institutes of General Medical Sciences T32GM008545NIGMS NIH HHS P20 GM103638NIGMS NIH HHS P30 GM145499NIGMS NIH HHS T32 GM008545
6 · The paper itself

Abstract

The search for chemical indicators of life is a fundamental component of potential future spaceflight missions to ocean worlds. Capillary electrophoresis (CE) is a useful separation method for the determination of the small organic molecules, such as amino acids and nucleobases, that could be used to help determine whether or not life is present in a sample collected during such missions. CE is under development for spaceflight applications using multiple detection systems, such as laser induced fluorescence (LIF) and mass spectrometry (MS). Here we report CE-based methods for separation and detection of major polar metabolites in cells, such as amino acids, nucleobases/sides, and oxidized and reduced glutathione using detectors that are less expensive alternatives to LIF and MS. Direct UV detection, indirect UV detection, and capacitvely coupled contactless conductivity detection (C

Indexed as

Electrophoresis, CapillaryEscherichia coliSpace FlightAmino AcidsGlutathionePseudoalteromonasAmino AcidsGlutathionebacteria analysisbiosignaturescapacitively coupled contactless conductivity detectioncapillary electrophoresismetabolic profiling

Identifiers

PMID38924581
PMCPMC11502272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.