Evidence map›Paper›PMID 38924516›Full record

ArticleJournal of the American Chemical Society2024

Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O-Arylation of Amino Alcohols.

Michael J Strauss, Kaylee X Liu, Megan E Greaves, Jakob C Dahl, Seoung-Tae Kim, Yong-Jin Wu, Michael A Schmidt, Paul M Scola, Stephen L Buchwald

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Base-Free C-N Cross-Electrophile Coupling.Journal of the American Chemical Society · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Efficient Aminations of Aryl Halides by a Cu(II) Catalyst.Journal of the American Chemical Society · 2025
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael J StraussDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States.ORCID 0000-0003-0808-2568
Kaylee X LiuDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States.ORCID 0009-0004-3059-8450
Megan E GreavesDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States.
Jakob C DahlDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-1443-8877
Seoung-Tae KimDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States.ORCID 0000-0003-4067-9567
Yong-Jin WuDepartment of Discovery Chemistry, Bristol Myers Squibb, 250 Water St., Cambridge, Massachusetts 02141, United States.ORCID 0000-0002-3452-6292
Michael A SchmidtChemical Process Development, Bristol Myers Squibb, 1 Squibb Dr. New Brunswick, New Jersey 08901, United States.ORCID 0000-0002-4880-2083
Paul M ScolaDepartment of Discovery Chemistry, Bristol Myers Squibb, 250 Water St., Cambridge, Massachusetts 02141, United States.
Stephen L BuchwaldDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States.ORCID 0000-0003-3875-4775

Funding

Metal-Catalyzed Methods for Organic SynthesisR35GM122483 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI STEPHEN L BUCHWALD · 2017 to 2026
$11.4M
Enantioselective Thioetherification of Olefins Guided by CuH CatalysisF32GM146391 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI STRAUSS, MICHAEL · 2022 to 2024
$210k
NIGMS NIH HHS F32 GM146391NIGMS NIH HHS R35 GM122483
6 · The paper itself

Abstract

We report a general and functional-group-tolerant method for the Cu-catalyzed amination of base-sensitive aryl bromides including substrates possessing acidic functional groups and small five-membered heteroarenes. The results presented herein substantially expand the scope of Cu-catalyzed C-N coupling reactions. The combination of

Indexed as

Amino AlcoholsCopperAminationBromidesCatalysisHydrocarbons, BrominatedLigandsMolecular StructureAmino AlcoholsBromidesCopperHydrocarbons, BrominatedLigands

Identifiers

PMID38924516
PMCPMC11375568

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.